Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LPL | P06858 | 2/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 6/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19211744 | 0.88 | KDM4E (0.52) | ROCK1KDM4ESMN1; SMN2LPLLIPG | |
| SCHEMBL21644162 | 0.87 | KDM4E (0.55) | ROCK1KDM4ESMN1; SMN2LPLLIPG | |
| SCHEMBL18579955 | 0.86 | ROCK1 (0.53) | ROCK1KDM4ESMN1; SMN2LPLLIPG | |
| SCHEMBL428922 | 0.86 | CYP2A13 (0.50) | ROCK1KDM4ESMN1; SMN2LPLLIPG | |
| SCHEMBL20680449 | 0.85 | ROCK1 (0.47) | ROCK1KDM4ESMN1; SMN2LPLLIPG | |
| SCHEMBL20198185 | 0.85 | ROCK1 (0.49) | ROCK1KDM4ESMN1; SMN2LPLLIPG | |
| SCHEMBL3264764 | 0.85 | ROCK1 (0.52) | ROCK1KDM4ESMN1; SMN2LPLLIPG | |
| SCHEMBL2798956 | 0.83 | ROCK1 (0.50) | ROCK1KDM4ESMN1; SMN2LPLLIPG | |
| SCHEMBL13517081 | 0.81 | ROCK1 (0.48) | ROCK1KDM4ESMN1; SMN2LPLLIPG | |
| SCHEMBL3263594 | 0.81 | ROCK1 (0.50) | ROCK1KDM4ESMN1; SMN2LPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010189-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |