Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 17/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264277 | 0.79 | CTSK (0.76) | CTSKCTSB | |
| SCHEMBL2243179 | 0.79 | CTSK (0.76) | CTSKCTSB | |
| SCHEMBL14563005 | 0.78 | CTSK (0.61) | CTSKCTSB | |
| SCHEMBL2249919 | 0.75 | CTSK (0.45) | CTSKCTSBCTSS | |
| SCHEMBL2243809 | 0.73 | CTSK (0.78) | CTSKCTSB | |
| SCHEMBL14563095 | 0.72 | CTSK (0.63) | CTSKCTSB | |
| SCHEMBL2241877 | 0.72 | CTSK (0.74) | CTSKCTSB | |
| SCHEMBL14563131 | 0.71 | CTSK (0.60) | CTSKCTSB | |
| SCHEMBL4789865 | 0.71 | KEAP1 (0.51) | CTSKCTSBCTSS | |
| SCHEMBL4789292 | 0.71 | NAMPT (0.38) | CTSKCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170879-A1 | 1-CYANOCYCLOPROPYL-DERIVATIVES AS CATHEPSIN K INHIBITORS | AstraZeneca AB (SE) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009001129-A9 | 1-CYANOCYCLOPROPYL-DERIVATIVES AS CATHEPSIN K INHIBITORS | ASTRAZENECA AB (SE) | 2010-02-04 | — | — | WO | disclosed |
| WO-2009001129-A1 | 1-CYANOCYCLOPROPYL-DERIVATIVES AS CATHEPSIN K INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |