Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.48 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.48 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.48 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264683 | 0.83 | CNR2 (0.49) | CNR2CNR1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL2273526 | 0.80 | CNR2 (0.45) | CNR2CNR1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL17478716 | 0.78 | PRKAB2 (0.50) | CNR2CNR1LRRK2PRKAB2PRKAG1 | |
| SCHEMBL17479078 | 0.74 | ALDH1A1 (0.42) | CNR2CNR1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL17478688 | 0.74 | LRRK2 (0.46) | CNR2LRRK2 | |
| SCHEMBL17478785 | 0.74 | GAK (0.51) | CNR2CNR1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL17479159 | 0.73 | CNR2 (0.40) | CNR2CNR1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL17478815 | 0.73 | CYP1A2 (0.52) | CNR2TSHRMEN1KMT2ALMNA | |
| SCHEMBL4909244 | 0.72 | TOP2A (0.48) | CNR2CNR1SMN1; SMN2MTORRAB9A | |
| SCHEMBL23779628 | 0.72 | CNR2 (0.59) | CNR2CNR1GAATP53DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184981-A1 | PYRIDINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009020642-A1 | PYRIDINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2009-02-12 | — | — | WO | disclosed |