⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9697890 | 0.97 | — | — | |
| Diallyl Sulfide SCHEMBL27594427 | 0.83 | ALOX5 (0.65) | — | |
| SCHEMBL5847169 | 0.81 | ALOX5 (0.53) | — | |
| SCHEMBL173833 | 0.79 | — | — | |
| SCHEMBL9287637 | 0.78 | — | — | |
| SCHEMBL9471474 | 0.77 | — | — | |
| SCHEMBL9130835 | 0.77 | — | — | |
| SCHEMBL11875926 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL11598999 | 0.77 | — | — | |
| SCHEMBL10748358 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9630909-B2 | Process for the preparation of nepafenac | MYLAN LABORATORIES LTD (IN) | 2017-04-25 | — | — | US | disclosed |
| US-9630909-B2 | Process for the preparation of nepafenac | MYLAN LABORATORIES LTD (IN) | 2017-04-25 | — | — | US | disclosed |
| US-20160214927-A1 | Process for the preparation of nepafenac | MYLAN LABORATORIES LTD, (IN) | 2016-07-28 | — | — | US | disclosed |
| US-20160214927-A1 | Process for the preparation of nepafenac | MYLAN LABORATORIES LTD, (IN) | 2016-07-28 | — | — | US | disclosed |
| EP-3013790-A1 | PROCESS FOR THE PREPARATION OF NEPAFENAC | Mylan Laboratories Ltd. (IN) | 2016-05-04 | — | — | EP | disclosed |
| EP-3013790-A1 | PROCESS FOR THE PREPARATION OF NEPAFENAC | Mylan Laboratories Ltd. (IN) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014207769-A1 | PROCESS FOR THE PREPARATION OF NEPAFENAC | MYLAN LABORATORIES LTD (IN) | 2014-12-31 | — | — | WO | disclosed |
| WO-2014207769-A1 | PROCESS FOR THE PREPARATION OF NEPAFENAC | MYLAN LABORATORIES LTD (IN) | 2014-12-31 | — | — | WO | disclosed |
| US-8440862-B2 | Process for preparing β-amino-α-hydroxycarboxamides | EVONIK DEGUSSA GMBH (DE) | 2013-05-14 | — | — | US | disclosed |
| US-20100010242-A1 | Process for Preparing beta-Amino-alpha-Hydroxycarboxamides | DEGUSSA GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
| US-7612237-B2 | By reaction between epoxycarboxamides and ammonia or amines and enantioselectively crystallizing the salts of racemic diastereomerically enriched compounds using a chiral organic acid | DEGUSSA GMBH (DE) | 2009-11-03 | — | — | US | disclosed |
| US-20080015368-A1 | Process for preparing beta-amino-alpha-hydroxycarboxamides | DEGUSSA GMBH (DE) | 2008-01-17 | — | — | US | disclosed |
| US-5395931-A | 6-amido-1-methyl-2-(substituted-thio)carbapenems | MERCK & CO., INC. (US) | 1995-03-07 | — | — | US | disclosed |
| EP-0350210-A2 | Novel 6-amido-1-methyl-2-(substituted-thio)-carbapenems | MERCK & CO. INC. (US) | 1990-01-10 | — | — | EP | disclosed |
| EP-0272909-A2 | Synthesis of aminothioacetamides | ELI LILLY AND COMPANY (US) | 1988-06-29 | — | — | EP | disclosed |