Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 15/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.39 |
| ▸ | PDE8B | O95263 | 3/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL567026 | 1.00 | TLR7 (0.41) | TLR7TLR8PDE8BADORA2AADORA2B | |
| SCHEMBL2197707 | 0.94 | TLR7 (0.44) | TLR7TLR8PDE8BADORA2AADORA2B | |
| SCHEMBL29697240 | 0.94 | TLR7 (0.44) | TLR7TLR8PDE8BADORA2AADORA2B | |
| SCHEMBL2195829 | 0.94 | TLR7 (0.44) | TLR7TLR8PDE8BADORA2AADORA2B | |
| SCHEMBL565796 | 0.94 | TLR7 (0.44) | TLR7TLR8PDE8BADORA2AADORA2B | |
| SCHEMBL20701858 | 0.90 | ADORA2A (0.41) | TLR7TLR8PDE8BADORA2AADORA2B | |
| SCHEMBL566039 | 0.90 | ADORA2A (0.41) | TLR7TLR8PDE8BADORA2AADORA2B | |
| SCHEMBL20275367 | 0.88 | YTHDC1 (0.37) | TLR7TLR8ADORA3 | |
| SCHEMBL1865662 | 0.88 | TLR7 (0.41) | TLR7TLR8PDE8BADORA2AADORA2B | |
| SCHEMBL565898 | 0.88 | TLR7 (0.41) | TLR7TLR8PDE8BADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010018131-A1 | PURINE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC, INFLAMMATORY AND INFECTIOUS DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-18 | — | — | WO | disclosed |
| WO-2010018133-A1 | PURINE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC, INFLAMMATORY AND INFECTIOUS DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-18 | — | — | WO | disclosed |