Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 16/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264992 | 0.76 | ROCK2 (0.72) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3265254 | 0.69 | ROCK2 (0.53) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3265256 | 0.69 | ROCK2 (0.53) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3247331 | 0.67 | ROCK2 (0.51) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3242441 | 0.66 | ROCK2 (0.49) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3248728 | 0.66 | ROCK2 (0.53) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3244390 | 0.64 | ROCK2 (0.50) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3252994 | 0.64 | ROCK2 (0.49) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3240406 | 0.64 | ROCK2 (0.49) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3249420 | 0.63 | ROCK2 (1.00) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |