Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL683499 | 0.89 | POLB (0.38) | POLBTDP1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL29241266 | 0.80 | POLB (0.45) | POLBTDP1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL21894380 | 0.73 | POLB (0.40) | POLBTDP1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL951965 | 0.73 | MEN1 (0.51) | POLBTDP1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL7373297 | 0.72 | POLB (0.39) | POLBTDP1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL684214 | 0.72 | PDE4B (0.60) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL17867572 | 0.71 | NTRK1 (0.39) | POLBTDP1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL683558 | 0.71 | THRB (0.44) | POLBTDP1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL28801151 | 0.70 | POLB (0.38) | POLBTDP1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL22777570 | 0.69 | EIF4A3 (0.45) | POLBL3MBTL1MAPTPRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265603-A1 | INHIBITORS OF THE BMP SIGNALING PATHWAY | The General Hospital Corporation (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009114180-A1 | INHIBITORS OF THE BMP SIGNALING PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2009-09-17 | — | — | WO | disclosed |