SCHEMBL32660720

SCHEMBL32660720

O=C(Nc1cccc(Cl)c1)N1CCN(Cc2ccc3[nH]c(-c4ccccn4)nc3c2)CC1

nearest known ligand 0.59

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FAAH O00519 16/20 0.59
SMN1; SMN2 Q16637 2/20 0.58
NPC1 O15118 2/20 0.58
RAB9A P51151 2/20 0.58
KDM4E B2RXH2 1/20 0.58
MAPT P10636 1/20 0.58
TSHR P16473 1/20 0.58
NLRP3 Q96P20 1/20 0.49
LMNA P02545 1/20 0.47
KMT2A Q03164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32660727 0.88 FAAH (0.57) FAAHMAPTLMNAKMT2A
SCHEMBL32660762 0.87 MEN1 (0.47) FAAHNPC1RAB9AKDM4EMAPT
SCHEMBL32660735 0.87 FAAH (0.51) FAAHSMN1; SMN2NPC1RAB9AKDM4E
SCHEMBL19970781 0.87 FAAH (0.57) FAAHSMN1; SMN2NPC1RAB9AKDM4E
SCHEMBL32660773 0.87 FAAH (0.57) FAAHSMN1; SMN2NPC1RAB9AKDM4E
SCHEMBL32660761 0.85 FAAH (0.57) FAAHSMN1; SMN2NPC1RAB9AKDM4E
SCHEMBL32660770 0.85 FAAH (0.59) FAAHSMN1; SMN2KMT2A
SCHEMBL19970861 0.85 FAAH (0.57) FAAH
SCHEMBL32660769 0.85 FAAH (0.57) FAAH
SCHEMBL32660738 0.84 MEN1 (0.53) FAAHNPC1RAB9AKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4678234-A1 ANTAGONIST HETEROCYCLIC COMPOUNDS INVOLVED IN THE CGAS-STING ROUTE Centre National de la Recherche Scientifique (FR) 2026-01-14 EP disclosed