Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 5/20 | 0.46 |
| ▸ | FDPS | P14324 | 10/20 | 0.38 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL808750 | 0.83 | FDPS (0.48) | FDPSGGPS1 | |
| SCHEMBL11572196 | 0.81 | FDPS (0.50) | FDPSGGPS1 | |
| SCHEMBL2346921 | 0.81 | FDPS (0.50) | FDPSGGPS1 | |
| SCHEMBL9374930 | 0.81 | FDPS (0.50) | FDPSGGPS1 | |
| SCHEMBL2669436 | 0.81 | FDPS (0.50) | FDPSGGPS1 | |
| SCHEMBL5176670 | 0.81 | FDPS (0.50) | FDPSGGPS1 | |
| SCHEMBL7050980 | 0.81 | FDPS (0.50) | FDPSGGPS1 | |
| SCHEMBL8528159 | 0.81 | FDPS (0.50) | FDPSGGPS1 | |
| SCHEMBL4952756 | 0.81 | FDPS (0.50) | FDPSGGPS1 | |
| SCHEMBL5672619 | 0.81 | FDPS (0.50) | FDPSGGPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636169-B1 | METHOD FOR DEHYDRATING SUBSTITUTED 4-DIMETHYLAMINO-2-ARYL-BUTAN-2-OL COMPOUNDS AND METHOD FOR PRODUCING SUBSTITUTED DIMETHYL-(3-ARYL-BUTYL)-AMINE COMPOUNDS BY MEANS OF HETEROGENEOUS CATALYSIS | GRUENENTHAL GMBH (DE) | 2010-06-02 | — | — | EP | claimed |
| EP-2792668-B1 | Process for the preparation of substituted 3-(1-amino-2-methyl-pentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2017-05-31 | — | — | EP | disclosed |
| EP-2666765-B1 | Process for the preparation of substituted 3-(1-amino-2-methyl-pentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2017-01-04 | — | — | EP | disclosed |
| US-8791300-B2 | Process for preparing a substituted dimethyl-(3-arylbutyl)amine compound by homogeneous catalysis | GRUENENTHAL GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8704002-B2 | Process for the dehydration of substituted 4-dimethylamino-2-aryl-butan-2-ol compounds and process for the preparation of substituted dimethyl-(3-aryl-butyl)-amine compounds by heterogeneous catalysis | Grünenthal GmbH (DE) | 2014-04-22 | — | — | US | disclosed |
| US-8704002-B2 | Process for the dehydration of substituted 4-dimethylamino-2-aryl-butan-2-ol compounds and process for the preparation of substituted dimethyl-(3-aryl-butyl)-amine compounds by heterogeneous catalysis | Grünenthal GmbH (DE) | 2014-04-22 | — | — | US | disclosed |
| US-8704002-B2 | Process for the dehydration of substituted 4-dimethylamino-2-aryl-butan-2-ol compounds and process for the preparation of substituted dimethyl-(3-aryl-butyl)-amine compounds by heterogeneous catalysis | Grünenthal GmbH (DE) | 2014-04-22 | — | — | US | disclosed |
| US-20130060065-A1 | Process for the Dehydration of Substituted 4-Dimethylamino-2-aryl-butan-2-ol Compounds and Process for the Preparation of Substituted Dimethyl-(3-aryl-butyl)- Amine Compounds by Heterogeneous Catalysis | GRUENENTHAL GMBH (DE) | 2013-03-07 | — | — | US | disclosed |
| US-20130060065-A1 | Process for the Dehydration of Substituted 4-Dimethylamino-2-aryl-butan-2-ol Compounds and Process for the Preparation of Substituted Dimethyl-(3-aryl-butyl)- Amine Compounds by Heterogeneous Catalysis | GRUENENTHAL GMBH (DE) | 2013-03-07 | — | — | US | disclosed |
| US-20130060065-A1 | Process for the Dehydration of Substituted 4-Dimethylamino-2-aryl-butan-2-ol Compounds and Process for the Preparation of Substituted Dimethyl-(3-aryl-butyl)- Amine Compounds by Heterogeneous Catalysis | GRUENENTHAL GMBH (DE) | 2013-03-07 | — | — | US | disclosed |
| WO-2007051576-A1 | PROCESS FOR PREPARING SUBSTITUTED DIMETHYL(3-ARYLBUTYL)AMINE COMPOUNDS BY MEANS OF HOMOGENEOUS CATALYSIS | Grünenthal GmbH (DE) | 2007-05-10 | — | — | WO | disclosed |
| US-20060167318-A1 | Process for the dehydration of substituted 4-dimethylamino-2-aryl-butan-2-ol compounds and process for the preparation of substituted dimethyl-(3-aryl-butyl)- amine compounds by heterogeneous catalysis | GRUENENTHAL GMBH (DE) | 2006-07-27 | — | — | US | disclosed |
| US-20060167318-A1 | Process for the dehydration of substituted 4-dimethylamino-2-aryl-butan-2-ol compounds and process for the preparation of substituted dimethyl-(3-aryl-butyl)- amine compounds by heterogeneous catalysis | GRUENENTHAL GMBH (DE) | 2006-07-27 | — | — | US | disclosed |
| US-20060167318-A1 | Process for the dehydration of substituted 4-dimethylamino-2-aryl-butan-2-ol compounds and process for the preparation of substituted dimethyl-(3-aryl-butyl)- amine compounds by heterogeneous catalysis | GRUENENTHAL GMBH (DE) | 2006-07-27 | — | — | US | disclosed |
| CN-1809527-A | Method for dehydrating substituted 4-dimethylamino-2-aryl-butan-2-ol compounds and method for preparing substituted dimethyl- (3-aryl-butyl) -amine compounds by heterogeneous catalysis | GRUENENTHAL GMBH (DE) | 2006-07-26 | — | — | CN | disclosed |
| CN-1809527-A | Method for dehydrating substituted 4-dimethylamino-2-aryl-butan-2-ol compounds and method for preparing substituted dimethyl- (3-aryl-butyl) -amine compounds by heterogeneous catalysis | GRUENENTHAL GMBH (DE) | 2006-07-26 | — | — | CN | disclosed |
| EP-1636169-A1 | METHOD FOR DEHYDRATING SUBSTITUTED 4-DIMETHYLAMINO-2-ARYL-BUTAN-2-OL COMPOUNDS AND METHOD FOR PRODUCING SUBSTITUTED DIMETHYL-(3-ARYL-BUTYL)-AMINE COMPOUNDS BY MEANS OF HETEROGENEOUS CATALYSIS | Grünenthal GmbH (DE) | 2006-03-22 | — | — | EP | disclosed |
| EP-1636169-A1 | METHOD FOR DEHYDRATING SUBSTITUTED 4-DIMETHYLAMINO-2-ARYL-BUTAN-2-OL COMPOUNDS AND METHOD FOR PRODUCING SUBSTITUTED DIMETHYL-(3-ARYL-BUTYL)-AMINE COMPOUNDS BY MEANS OF HETEROGENEOUS CATALYSIS | Grünenthal GmbH (DE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2005000788-A1 | METHOD FOR DEHYDRATING SUBSTITUTED 4-DIMETHYLAMINO-2-ARYL-BUTAN-2-OL COMPOUNDS AND METHOD FOR PRODUCING SUBSTITUTED DIMETHYL-(3-ARYL-BUTYL)-AMINE COMPOUNDS BY MEANS OF HETEROGENEOUS CATALYSIS | Grünenthal GmbH (DE) | 2005-01-06 | — | — | WO | disclosed |
| WO-2005000788-A1 | METHOD FOR DEHYDRATING SUBSTITUTED 4-DIMETHYLAMINO-2-ARYL-BUTAN-2-OL COMPOUNDS AND METHOD FOR PRODUCING SUBSTITUTED DIMETHYL-(3-ARYL-BUTYL)-AMINE COMPOUNDS BY MEANS OF HETEROGENEOUS CATALYSIS | Grünenthal GmbH (DE) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167318-A1 | Process for the dehydration of substituted 4-dimethylamino-2-aryl-butan-2-ol compounds and process for the preparation of substituted dimethyl-(3-aryl-butyl)- amine compounds by heterogeneous catalysis | BRD2, BBOX1, BRD1 | DNM1 2950/4885FDPS 2232/4885GGPS1 3431/4885 |
| US-20130060065-A1 | Process for the Dehydration of Substituted 4-Dimethylamino-2-aryl-butan-2-ol Compounds and Process for the Preparation of Substituted Dimethyl-(3-aryl-butyl)- Amine Compounds by Heterogeneous Catalysis | BRD2, BBOX1, BRD1 | DNM1 2950/4885FDPS 2232/4885GGPS1 3431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.