SCHEMBL32669772

SCHEMBL32669772

CN(Cc1cc2c(cc1F)CCOC2)C(=O)/C(C#N)=C(\O)c1cc(Cl)c(O)c([N+](=O)[O-])c1

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FTO Q9C0B1 6/20 0.45
COMT P21964 5/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32669864 0.93 FTO (0.54) FTOCOMT
SCHEMBL32669673 0.90 FTO (0.44) FTOCOMT
SCHEMBL32669652 0.82 FTO (0.49) FTOCOMT
SCHEMBL32669988 0.81 COMT (0.52) FTOCOMT
SCHEMBL32669661 0.80 FTO (0.49) FTOCOMT
SCHEMBL32669732 0.79 COMT (0.34) FTOCOMT
SCHEMBL32669706 0.79 COMT (0.34) FTOCOMT
SCHEMBL32669806 0.78 FTO (0.45) FTOCOMT
SCHEMBL32669528 0.78 FTO (0.45) FTOCOMT
SCHEMBL32669701 0.77 FTO (0.62) FTOCOMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035341-A1 FTO INHIBITORS RPXDS CO LTD (CN) 2026-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035341-A1 FTO INHIBITORS FTO, LDLR, GPR119 FTO 1/4885COMT 52/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.