Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 4/20 | 0.55 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159854 | 0.85 | SOS1 (0.50) | SOS1HTR2ASLC6A4KCNH2TTR | |
| SCHEMBL4345160 | 0.84 | SOS1 (0.65) | SOS1HTR2ASLC6A4KCNH2EGFR | |
| SCHEMBL923443 | 0.84 | ST14 (0.58) | SOS1HTR2ASLC6A4KCNH2EGFR | |
| SCHEMBL14656127 | 0.84 | SOS1 (0.54) | SOS1HTR2ASLC6A4KCNH2EGFR | |
| SCHEMBL14656136 | 0.81 | SOS1 (0.51) | SOS1HTR2ASLC6A4KCNH2EGFR | |
| SCHEMBL14662201 | 0.79 | SOS1 (0.60) | SOS1HTR2ASLC6A4KCNH2EGFR | |
| SCHEMBL9505024 | 0.79 | TTR (0.37) | SOS1HTR2ASLC6A4KCNH2TTR | |
| SCHEMBL9502682 | 0.79 | HTR2A (0.46) | HTR2ASLC6A4KCNH2TTRCHEK2 | |
| SCHEMBL2987196 | 0.78 | MAOB (0.54) | HTR2ASLC6A4KCNH2TTRPPARG | |
| SCHEMBL1503218 | 0.78 | PIK3CA (0.45) | SOS1SLC6A4TTRMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260035364-A1 | BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2026-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260035364-A1 | BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES | SCN1B, SCN2B, SCN11A | SOS1 798/4885HTR2A 273/4885SLC6A4 170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.