Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | RPA1 | P27694 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23850015 | 0.82 | TAAR1 (0.47) | PIK3CADAOPNMTTAAR1HDAC3 | |
| SCHEMBL16388285 | 0.81 | PIK3CA (0.45) | PIK3CADAOPNMTTAAR1HDAC3 | |
| SCHEMBL4524759 | 0.81 | MAPT (0.42) | TTRPNMTTAAR1MAPTIDO1 | |
| SCHEMBL31634179 | 0.81 | MAPT (0.42) | TTRPNMTTAAR1MAPTIDO1 | |
| SCHEMBL1503157 | 0.80 | HTT (0.45) | DAOTTRALDH1A1HTTMAOB | |
| SCHEMBL29489387 | 0.80 | HTT (0.45) | DAOTTRALDH1A1HTTMAOB | |
| SCHEMBL257081 | 0.79 | TSHR (0.44) | PIK3CADAOPNMTTAAR1HDAC3 | |
| SCHEMBL151278 | 0.79 | PIK3CA (0.44) | PIK3CADAOPNMTTAAR1HDAC3 | |
| SCHEMBL42421 | 0.79 | CSNK2A1 (0.50) | PIK3CAPNMTTAAR1SLC6A4SLC6A3 | |
| SCHEMBL2195620 | 0.79 | PIK3CA (0.47) | PIK3CADAOTTRHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3455224-B1 | SUBSTITUTED 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3(2H)-ONES AND 2,5,6,7-TETRAHYDRO-3H-PYRROLO[2,1-C][1,2,4]TRIAZOL-3-ONES, AND USE THEREOF | BAYER AG (DE) | 2024-03-27 | — | — | EP | disclosed |
| CN-111655678-B | Apoptosis signal regulating kinase-1 inhibitor and application thereof | 广州市恒诺康医药科技有限公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-116322759-A | Phospholipid compounds and uses thereof | 吉利德科学公司 | 2023-06-23 | — | — | CN | disclosed |
| WO-2023016278-A1 | ISOXAZOLE-CONTAINING PYRIDINOPYRIMIDINONE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | 贵州大学 | 2023-02-16 | — | — | WO | disclosed |
| US-11504371-B2 | Quinazolines compound, preparation method therefor and application thereof | BEIJING NORMAL UNIVERSITY (CN) | 2022-11-22 | — | — | US | disclosed |
| CN-113651811-B | Isoxazole-containing pyridopyrimidone compound and preparation method and application thereof | 贵州大学 | 2022-06-07 | — | — | CN | disclosed |
| CN-113651811-A | Isoxazole-containing pyridopyrimidone compound and preparation method and application thereof | 贵州大学 | 2021-11-16 | — | — | CN | disclosed |
| CN-112028870-B | Compound with benzyloxy aromatic ring structure, preparation method and application thereof | 中国科学院上海药物研究所 | 2021-11-05 | — | — | CN | disclosed |
| CN-111269215-B | Nitrogen-containing heterocyclic organic compound and preparation method and application thereof | 中科利健制药(广州)有限公司 | 2021-10-26 | — | — | CN | disclosed |
| CN-109476658-B | Substituted 5,6,7, 8-tetrahydro [1,2,4] triazolo [4,3-a ] pyridin-3 (2H) -ones and 2,5,6, 7-tetrahydro-3H-pyrrolo [2,1-c ] [1,2,4] triazol-3-ones and uses thereof | 拜耳公司 | 2021-08-10 | — | — | CN | disclosed |
| US-9102674-B2 | Substituted naphthyridine and quinoline compounds as MAO inhibitors | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2015-08-11 | — | — | US | disclosed |
| US-20140315944-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | DART NEUROSCIENCE LLC | 2014-10-23 | — | — | US | disclosed |
| WO-2014158916-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | DART NEUROSCIENCE, LLC (US) | 2014-10-02 | — | — | WO | disclosed |
| US-20140275548-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | DART NEUROSCIENCE LLC | 2014-09-18 | — | — | US | disclosed |
| US-8742123-B2 | HIV integrase inhibitors from pyridoxine | TAIMED BIOLOGICS, INC. (TW) | 2014-06-03 | — | — | US | disclosed |
| US-20110178120-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | AMBRILIA BIOPHARMA, INC. (CA) | 2011-07-21 | — | — | US | disclosed |
| CN-102112447-A | HIV integrase inhibitors from pyridoxine | AMBRILIA BIOPHARMA INC | 2011-06-29 | — | — | CN | disclosed |
| EP-2300433-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | Ambrilia Biopharma Inc. (CA) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009146555-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | AMBRILIA BIOPHARMA INC. (CA) | 2009-12-10 | — | — | WO | disclosed |
| WO-2004085409-A2 | COMPOUNDS AND LIBRARIES OF PYRIDINES, PYRAZINES, IMIDAZO[1,2-A]PYRAZINES AND 1H-IMIDAZO[4,5-B]PYRAZIN-2-ONES AND FIRST AND SECOND MEDICAL USES THEREOF | BIOFOCUS DISCOVERY LTD (GB) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178120-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | PNPO, CCNB1, BLVRB | PIK3CA 575/4885DAO 1064/4885TTR 2698/4885 |
| US-20140275548-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | MAOB, MAOA, PNMT | PIK3CA 1685/4885DAO 415/4885TTR 2689/4885 |
| US-20140315944-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | MAOB, MAOA, PNMT | PIK3CA 1685/4885DAO 421/4885TTR 2596/4885 |
| US-11504371-B2 | Quinazolines compound, preparation method therefor and application thereof | WEE1, WEE2, SLC38A7 | PIK3CA 410/4885DAO 2715/4885TTR 4439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.