Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.53 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264835 | 0.90 | SMN1; SMN2 (0.54) | SMN1; SMN2PSMB1PSMB5PSMB2MEN1 | |
| SCHEMBL10805417 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2PSMB1PSMB5PSMB2MEN1 | |
| SCHEMBL1586530 | 0.88 | KDM4E (0.54) | SMN1; SMN2MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL14349534 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2PSMB1PSMB5PSMB2MEN1 | |
| SCHEMBL18974725 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2PSMB1PSMB5PSMB2MEN1 | |
| SCHEMBL8140756 | 0.82 | NPC1 (0.47) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL84118 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2PSMB1PSMB5PSMB2MEN1 | |
| SCHEMBL4738149 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2PSMB1PSMB5PSMB2MEN1 | |
| SCHEMBL4745368 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2PSMB1PSMB5PSMB2MEN1 | |
| SCHEMBL25316696 | 0.80 | SMN1; SMN2 (0.39) | SMN1; SMN2PSMB1PSMB5PSMB2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017216579-A1 | AUTOPHAGY INDUCER COMPOUNDS | EPSILON-3 BIO LIMITED (GB) | 2017-12-21 | — | — | WO | disclosed |
| EP-2139878-A2 | HIGH REFRACTIVE INDEX MONOMERS, COMPOSITIONS AND USES THEREOF | BASF SE (DE) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008101806-A2 | HIGH REFRACTIVE INDEX MONOMERS, COMPOSITIONS AND USES THEREOF | BASF SE (CH) | 2008-08-28 | — | — | WO | disclosed |
| US-20080200582-A1 | High refractive index monomers, compositions and uses thereof | CIBA CORP. | 2008-08-21 | — | — | US | disclosed |