Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.30 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3742088 | 0.82 | BACE1 (0.30) | — | |
| SCHEMBL3732302 | 0.80 | HTR2A (0.36) | HTR2AHTR2CHTR2BMAPTNPSR1 | |
| SCHEMBL2527649 | 0.80 | MAPK1 (0.38) | HTR2AHTR2CHTR2BMAPK1DPP4 | |
| SCHEMBL3737454 | 0.80 | BACE1 (0.31) | — | |
| SCHEMBL730684 | 0.78 | TP53 (0.38) | HTR2AHTR2CHTR2BMAPK1DPP4 | |
| SCHEMBL3745117 | 0.75 | BACE1 (0.31) | — | |
| SCHEMBL3755662 | 0.75 | HPGD (0.39) | HTR2AHTR2CHTR2BMAPK1DPP4 | |
| SCHEMBL3394216 | 0.74 | MAPK1 (0.36) | HTR2AHTR2CHTR2BMAPK1DPP4 | |
| SCHEMBL13076982 | 0.69 | PTGS2 (0.35) | CNR2CNR1SLC6A3 | |
| SCHEMBL16556753 | 0.68 | ACACB (0.34) | MAPTALDH1A1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195290-B1 | HALOGEN ALKOXY SPIROCYCLIC TETRAMIC AND TETRONIC ACID DERIVATIVES | BAYER IP GMBH (DE) | 2015-03-11 | — | — | EP | disclosed |
| US-8435549-B2 | Halogen alkoxy spirocyclic tetramic and tetronic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2013-05-07 | — | — | US | disclosed |
| US-20100279873-A1 | Halogen Alkoxy Spirocyclic Tetramic and Tetronic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2010-11-04 | — | — | US | disclosed |
| EP-2195290-A1 | HALOGEN ALKOXY SPIROCYCLIC TETRAMIC AND TETRONIC ACID DERIVATIVES | Bayer CropScience AG (DE) | 2010-06-16 | — | — | EP | disclosed |
| EP-2045240-A1 | Halogen alkoxy spirocyclic tetram and tetron acid derivatives | Bayer CropScience AG (DE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2009039975-A1 | HALOGEN ALKOXY SPIROCYCLIC TETRAMIC AND TETRONIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2009-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100279873-A1 | Halogen Alkoxy Spirocyclic Tetramic and Tetronic Acid Derivatives | KCNA5, KCNH1, KCNQ5 | HTR2A 4026/4885HTR2C 4621/4885HTR2B 4235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.