SCHEMBL3267246

SCHEMBL3267246

CN(C(=O)/C=C/CC1(N)CCC1)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N(C)N(C)C

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 8/20 0.50
TACR1 P25103 2/20 0.36
PPARG P37231 1/20 0.34
PPARA Q07869 1/20 0.34
EPHX1 P07099 1/20 0.34
MMP9 P14780 1/20 0.34
MMP8 P22894 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3267249 1.00 GHSR (0.50) GHSRTACR1PPARGPPARAEPHX1
SCHEMBL6319068 0.90 GHSR (0.49) GHSRTACR1
SCHEMBL6319064 0.90 GHSR (0.49) GHSRTACR1
SCHEMBL867608 0.87 GHSR (0.45) GHSRTACR1
SCHEMBL7896416 0.87 GHSR (0.45) GHSRTACR1
SCHEMBL867607 0.87 GHSR (0.45) GHSRTACR1
SCHEMBL10039191 0.87 GHSR (0.46) GHSRTACR1
SCHEMBL1401013 0.86 GHSR (0.46) GHSRTACR1
SCHEMBL1401016 0.86 GHSR (0.46) GHSRTACR1
SCHEMBL4294256 0.86 GHSR (0.57) GHSRTACR1MMP9MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047709-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2004-11-03 EP claimed
EP-1047709-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 2000-11-02 EP claimed
WO-1999036431-A9 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2000-07-27 WO claimed
US-6083908-A TREATING MEDICAL DISORDERS RESULTING FROM DEFICIENCY IN GROWTH HORMONE NOVO NORDISK A/S (DK) 2000-07-04 US claimed
WO-1999036431-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1999-07-22 WO claimed
EP-1506969-B1 Compounds with growth hormone releasing properties HELSINN THERAPEUTICS US INC (US) 2010-06-09 EP disclosed
EP-1506969-A1 Compounds with growth hormone releasing properties NOVO NORDISK A/S (DK) 2005-02-16 EP disclosed
EP-1047709-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2004-11-03 EP disclosed
EP-1047709-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 2000-11-02 EP disclosed
WO-1999036431-A9 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2000-07-27 WO disclosed
US-6083908-A TREATING MEDICAL DISORDERS RESULTING FROM DEFICIENCY IN GROWTH HORMONE NOVO NORDISK A/S (DK) 2000-07-04 US disclosed
WO-1999036431-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1999-07-22 WO disclosed