SCHEMBL2065680

SCHEMBL2065680

CCCCc1ccc2nc(Br)cn2n1

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 3/20 0.36
KCNH2 Q12809 1/20 0.35
AHR P35869 8/20 0.34
TLR7 Q9NYK1 3/20 0.33
NOS2 P35228 1/20 0.32
KDM5A P29375 1/20 0.31
KDM4C Q9H3R0 1/20 0.31
KDM5B Q9UGL1 1/20 0.31
TP53 P04637 1/20 0.30
MAPT P10636 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2066211 0.90 PDE10A (0.38) PDE10AAHRTP53SMN1; SMN2
SCHEMBL2067911 0.83 AHR (0.38) PDE10AAHR
SCHEMBL2065574 0.81 PDE10A (0.52) PDE10AKCNH2AHRTLR7NOS2
SCHEMBL2066270 0.81 PDE10A (0.37) PDE10AKCNH2AHRTLR7NOS2
SCHEMBL21386281 0.78 PDE10A (0.50) PDE10AKCNH2TP53MAPTSMN1; SMN2
SCHEMBL3267416 0.77 KCNH2 (0.41) PDE10AKCNH2TLR7NOS2TP53
SCHEMBL2066534 0.76 AHR (0.35) PDE10AAHRTLR7NOS2TP53
SCHEMBL2066636 0.75 PDE10A (0.40) PDE10ATP53SMN1; SMN2
SCHEMBL21835238 0.73 KDM4E (0.40) PDE10AKCNH2
SCHEMBL2068243 0.72 PDE10A (0.53) PDE10AAHRNOS2TP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8148524-B2 Process for producing sulfonyl chloride compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-04-03 US disclosed
EP-1932846-B1 METHOD FOR PRODUCING SULFONYL CHLORIDE COMPOUND SUMITOMO CHEMICAL CO (JP) 2010-10-27 EP disclosed
US-20090247748-A1 PROCESS FOR PRODUCING SULFONYL CHLORIDE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-10-01 US disclosed
EP-1932846-A1 METHOD FOR PRODUCING SULFONYL CHLORIDE COMPOUND Sumitomo Chemical Company, Limited (JP) 2008-06-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090247748-A1 PROCESS FOR PRODUCING SULFONYL CHLORIDE COMPOUND SALL4, CLCN2, CLIC1 PDE10A 3486/4885KCNH2 21/4885AHR 1818/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.