Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 10/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 8/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 8/20 | 0.49 |
| ▸ | F10 | P00742 | 6/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229940 | 0.90 | GRM2 (0.51) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7228315 | 0.88 | GRM2 (0.51) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7237867 | 0.88 | GRM2 (0.51) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7386950 | 0.87 | GRM2 (0.63) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL8151677 | 0.87 | GRM2 (0.57) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7227714 | 0.86 | GRM2 (0.51) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7239380 | 0.86 | GRM2 (0.53) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7227598 | 0.85 | GRM2 (0.50) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL3266803 | 0.85 | GRM2 (0.52) | GRM2ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL7239295 | 0.85 | GRM2 (0.52) | GRM2ITGB3PRSS1PRSS2ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602876-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2003-08-05 | — | — | US | claimed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | claimed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | claimed |
| JP-8225550-A | — | — | None | — | — | JP | disclosed |
| EP-0951295-B1 | COMPOSITIONS FOR USE IN INHIBITING OF ALPHA-V-BETA3 MEDIATED ANGIOGENESIS | SCRIPPS RESEARCH INST (US) | 2010-06-09 | — | — | EP | disclosed |
| US-20060270710-A1 | Methods for inhibition of angiogenesis | THE SCRIPPS RESEARCH INSTITUTE | 2006-11-30 | — | — | US | disclosed |
| US-20060165703-A1 | Methods and compositions useful for inhibition of alpha v beta 5 mediated angiogenesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-07-27 | — | — | US | disclosed |
| US-7053041-B1 | Methods and compositions useful for inhibition of αvβ5mediated angiogenesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-05-30 | — | — | US | disclosed |
| EP-1613268-A2 | METHODS FOR INHIBITION OF ANGIOGENESIS | The Scripps Research Institute (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004087057-A2 | METHODS FOR INHIBITION OF ANGIOGENESIS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2004-10-14 | — | — | WO | disclosed |
| US-20040063790-A1 | Methods for inhibition of angiogenesis | THE SCRIPPS RESEARCH INSTITUTE | 2004-04-01 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0844874-A1 | METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF $g(a) v?$g(b) 5? MEDIATED ANGIOGENESIS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1998-06-03 | — | — | EP | disclosed |
| WO-1997045447-A9 | METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF αvβ5 MEDIATED ANGIOGENESIS | — | 1998-03-12 | — | — | WO | disclosed |
| WO-1997045137-A1 | METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF ANGIOGENESIS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1997-12-04 | — | — | WO | disclosed |
| WO-1997045447-A1 | METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF αvβ5 MEDIATED ANGIOGENESIS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1997-12-04 | — | — | WO | disclosed |
| WO-1997006791-A9 | METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF αvβ5 MEDIATED ANGIOGENESIS | — | 1997-04-03 | — | — | WO | disclosed |
| WO-1997006791-A1 | METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF αvβ5 MEDIATED ANGIOGENESIS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1997-02-27 | — | — | WO | disclosed |
| JP-H08225550-A | ADHESION RECEPTOR ANTAGONIST | MERCK PATENT GMBH | 1996-09-03 | — | — | JP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063790-A1 | Methods for inhibition of angiogenesis | FLT4, ANXA3, VCAM1 | GRM2 1818/4885ITGB3 79/4885PRSS1 920/4885 |
| US-20060165703-A1 | Methods and compositions useful for inhibition of alpha v beta 5 mediated angiogenesis | ITGA5, ITGB5, ITGAV | GRM2 3382/4885ITGB3 11/4885PRSS1 2493/4885 |
| US-20060270710-A1 | Methods for inhibition of angiogenesis | FLT4, KDR, FLT1 | GRM2 2267/4885ITGB3 5/4885PRSS1 649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.