Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1741754 | 0.93 | L3MBTL1 (0.49) | BRD4ALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL3200239 | 0.82 | GPR119 (0.52) | MAPTMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL2474336 | 0.81 | SMN1; SMN2 (0.43) | ALDH1A1L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL13349784 | 0.76 | GPR119 (0.53) | MAPTMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL3537491 | 0.76 | TRPV1 (0.49) | ALDH1A1MAPTMEN1KMT2AGAA | |
| SCHEMBL1742452 | 0.76 | BRD4 (0.50) | BRD4ALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL3540342 | 0.73 | MEN1 (0.51) | ALDH1A1MAPTMEN1KMT2AGAA | |
| SCHEMBL1741730 | 0.72 | L3MBTL1 (0.53) | ALDH1A1L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL4705226 | 0.72 | GAA (0.58) | BRD4ALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL7666242 | 0.72 | SMN1; SMN2 (0.56) | MEN1KMT2ARBP4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139479-A2 | 4-[2-(4-METHYLPHENYLSULFANYL)PHENYL]PIPERIDINE WITH COMBINED SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITION FOR THE TREATMENT OF ADHD, MELANCHOLIA, TREATMENT RESISTENT DEPRESSION OR RESIDUAL SYMPTOMS IN DEPRESSION | H. Lundbeck A/S (DK) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008113360-A2 | 4- [2- (4-METHYLPHENYLSULFANYD-PHENYL] PIPERIDINE WITH COMBINED SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITION FOR THE TREATMENT OF ADHD, MELANCHOLIA, TREATMENT RESISTENT DEPRESSION OR RESIDUAL SYMPTOMS IN DEPRESSION | H. LUNDBECK A/S (DK) | 2008-09-25 | — | — | WO | disclosed |