SCHEMBL32680229

SCHEMBL32680229

Cc1ccc2[nH]c(-c3ncccc3Br)nc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CBFB Q13951 4/20 0.47
▸ METAP2 P50579 3/20 0.47
▸ METAP1 P53582 3/20 0.47
▸ NPC1 O15118 6/20 0.46
▸ RAB9A P51151 6/20 0.46
▸ PKM P14618 3/20 0.46
▸ ALDH1A1 P00352 4/20 0.44
▸ TRPV1 Q8NER1 1/20 0.44
▸ PDPK1 O15530 1/20 0.41
▸ ITK Q08881 2/20 0.40
▸ KDM4E B2RXH2 4/20 0.38
▸ MAPT P10636 3/20 0.38
▸ SMN1; SMN2 Q16637 3/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ RUNX1 Q01196 1/20 0.37
▸ TP53 P04637 1/20 0.37
▸ HPGD P15428 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL125119 0.86 CBFB (0.49) CBFBMETAP2METAP1NPC1RAB9A
SCHEMBL124418 0.83 CBFB (0.54) CBFBMETAP2METAP1NPC1RAB9A
SCHEMBL19228817 0.81 RUNX1 (0.57) CBFBMETAP2METAP1NPC1RAB9A
SCHEMBL19228812 0.80 RUNX1 (0.56) CBFBMETAP2METAP1NPC1RAB9A
SCHEMBL19228819 0.78 CBFB (0.46) CBFBMETAP2METAP1NPC1RAB9A
SCHEMBL19228827 0.77 CXCR3 (0.45) CBFBMETAP2METAP1NPC1RAB9A
SCHEMBL19228825 0.77 CBFB (0.41) CBFBMETAP2METAP1NPC1RAB9A
SCHEMBL32680204 0.77 NPC1 (0.42) CBFBMETAP2METAP1NPC1RAB9A
SCHEMBL1171203 0.77 NPC1 (0.51) CBFBMETAP2METAP1NPC1RAB9A
SCHEMBL19228826 0.76 ALOX5 (0.46) CBFBMETAP2METAP1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4702017-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd (KY) 2026-03-04 — — EP disclosed
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