SCHEMBL32686207

SCHEMBL32686207

COC(=O)c1cc2c(I)ccnc2s1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSNK2A2 P19784 2/20 0.50
CSNK2B P67870 2/20 0.50
CSNK2A1 P68400 2/20 0.50
KDR P35968 1/20 0.50
ABL1 P00519 1/20 0.46
BCR P11274 1/20 0.46
PAK4 O96013 1/20 0.45
AKT1 P31749 1/20 0.45
PLK1 P53350 1/20 0.45
ICAM1 P05362 2/20 0.42
SELE P16581 2/20 0.42
VCAM1 P19320 2/20 0.42
HPGD P15428 3/20 0.41
ALDH1A1 P00352 2/20 0.41
KDM4E B2RXH2 5/20 0.40
POLB P06746 2/20 0.40
TP53 P04637 1/20 0.40
HSD17B10 Q99714 1/20 0.40
NPC1 O15118 1/20 0.39
PKM P14618 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5424509 0.86 CDC7 (0.46) CSNK2A2CSNK2BCSNK2A1KDRICAM1
SCHEMBL8805684 0.82 CSNK2A2 (0.50) CSNK2A2CSNK2BCSNK2A1KDRABL1
SCHEMBL32686086 0.80 CSNK2A2 (0.48) CSNK2A2CSNK2BCSNK2A1KDRABL1
SCHEMBL6504831 0.77 CSNK2A2 (0.48) CSNK2A2CSNK2BCSNK2A1KDRABL1
SCHEMBL829725 0.73 SLC9A1 (0.56) CSNK2A2CSNK2BCSNK2A1KDRPAK4
SCHEMBL1098501 0.73 HPGD (0.54) CSNK2A2CSNK2BCSNK2A1KDRPAK4
SCHEMBL20399117 0.72 ABL1 (0.52) CSNK2A2CSNK2BCSNK2A1KDRABL1
SCHEMBL1937266 0.72 ABL1 (0.52) CSNK2A2CSNK2BCSNK2A1KDRABL1
SCHEMBL5461106 0.70 ABL1 (0.50) CSNK2A2CSNK2BCSNK2A1KDRABL1
SCHEMBL843921 0.69 KDM4E (0.54) CSNK2A2CSNK2BCSNK2A1KDRICAM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709480-A1 5,6-FUSED BICYCLIC AMIDES AND COMPOSITIONS FOR USE AS 15-PROSTAGLANDIN DEHYDROGENASE MODULATORS Amgen Inc. (US) 2026-03-18 EP disclosed