SCHEMBL32686844

SCHEMBL32686844

CC1c2cc(N)ccc2C(=O)N1Cc1ccc2c(c1)oc(=O)n2COCC[Si](C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ TNIK Q9UKE5 12/20 0.35
▸ MET P08581 1/20 0.34
▸ NPC1 O15118 1/20 0.33
▸ MIF P14174 2/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ LMNA P02545 1/20 0.31
▸ TSHR P16473 1/20 0.31
▸ HTT P42858 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ PDE10A Q9Y233 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32686876 0.93 TNIK (0.36) TNIKMETNPC1MIFALDH1A1
SCHEMBL32686731 0.90 MIF (0.39) TNIKNPC1MIFALDH1A1LMNA
SCHEMBL32686871 0.90 NPC1 (0.39) TNIKNPC1MIFALDH1A1LMNA
SCHEMBL32686806 0.90 NPC1 (0.39) TNIKNPC1MIFALDH1A1LMNA
SCHEMBL32686845 0.90 NPC1 (0.39) TNIKNPC1MIFALDH1A1LMNA
SCHEMBL32686743 0.89 TNIK (0.41) TNIKMETMIFLMNASMN1; SMN2
SCHEMBL31667652 0.88 NPC1 (0.46) TNIKNPC1MIFALDH1A1LMNA
SCHEMBL31667553 0.88 TNIK (0.32) TNIKNPC1MIF
SCHEMBL32686828 0.88 TNIK (0.32) TNIKNPC1MIF
SCHEMBL32686874 0.87 SIGMAR1 (0.41) TNIKNPC1MIFPDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078130-A1 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF SIRONAX LTD (KY) 2026-03-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078130-A1 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF NAMPT, NNMT, SARM1 TNIK 4286/4885MET 2688/4885NPC1 200/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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