SCHEMBL32688296

SCHEMBL32688296

CN(C)C(=O)c1ccc(-c2ccc(-c3c(C#N)c(SCc4nnn[nH]4)[nH]c(=O)c3C#N)cc2)cc1

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ ACMSD Q8TDX5 3/20 0.35
▸ HSD11B1 P28845 8/20 0.34
▸ NCOA1 Q15788 1/20 0.34
▸ NCOA3 Q9Y6Q9 1/20 0.34
▸ OTUD7B Q6GQQ9 2/20 0.33
▸ MMP2 P08253 1/20 0.32
▸ MMP9 P14780 1/20 0.32
▸ MMP8 P22894 1/20 0.32
▸ HSD11B2 P80365 1/20 0.32
▸ PDE9A O76083 2/20 0.31
▸ MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32688249 0.87 MEN1 (0.40) ACMSDHSD11B1PDE9A
SCHEMBL32688432 0.87 ADORA1 (0.40) HSD11B1HSD11B2PDE9A
SCHEMBL32688034 0.86 PDE9A (0.43) PDE9A
SCHEMBL32688422 0.85 MAPT (0.38) ACMSDHSD11B1MAPT
SCHEMBL32688269 0.85 HSD11B1 (0.45) ACMSDHSD11B1
SCHEMBL32688166 0.85 HSD11B1 (0.41) HSD11B1HSD11B2PDE9A
SCHEMBL32688008 0.85 MEN1 (0.42) ACMSDHSD11B1HSD11B2PDE9A
SCHEMBL32688160 0.84 HSD11B1 (0.36) HSD11B1HSD11B2
SCHEMBL32687990 0.83 ADORA1 (0.44) NCOA1NCOA3MAPT
SCHEMBL32688201 0.83 HSD11B1 (0.36) HSD11B1HSD11B2PDE9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors ORSOBIO INC (US) 2026-03-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors CPT1B, CBR1, MUSK ACMSD 142/4885HSD11B1 61/4885NCOA1 208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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