Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.63 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL325939 | 0.80 | MCHR1 (0.48) | MCHR1KCNH2 | |
| SCHEMBL327335 | 0.80 | MCHR1 (0.67) | MCHR1ADRB2KCNH2ALDH1A1MTNR1B | |
| SCHEMBL322333 | 0.77 | MCHR1 (1.00) | MCHR1KCNH2 | |
| SCHEMBL10242878 | 0.74 | MCHR1 (0.59) | MCHR1ADRB2KCNH2ALDH1A1MTNR1B | |
| SCHEMBL10190094 | 0.74 | MCHR1 (0.59) | MCHR1ADRB2KCNH2ALDH1A1MTNR1B | |
| SCHEMBL10264311 | 0.71 | MCHR1 (0.89) | MCHR1KCNH2 | |
| SCHEMBL321217 | 0.70 | ADRB2 (0.56) | MCHR1ADRB2KCNH2ALDH1A1MTNR1B | |
| SCHEMBL321388 | 0.70 | MCHR1 (1.00) | MCHR1KCNH2 | |
| SCHEMBL322065 | 0.70 | MCHR1 (0.52) | MCHR1ADRB2ALDH1A1MTNR1BKDM4E | |
| SCHEMBL322063 | 0.69 | MCHR1 (0.86) | MCHR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590969-A2 | THERAPEUTIC AGENTS 976 | AstraZeneca AB (SE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004588-A2 | THERAPEUTIC AGENTS 976 | ASTRAZENECA AB (SE) | 2012-01-12 | — | — | WO | disclosed |