SCHEMBL32689595

SCHEMBL32689595

NC(=O)CCNCc1ccnc(-c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c1

nearest known ligand 0.50

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 10/20 0.50
GSPT1 P15170 2/20 0.49
DDB1 Q16531 2/20 0.49
IKZF3 Q9UKT9 1/20 0.49
CSNK1A1 P48729 2/20 0.49
CYP2C19 P33261 1/20 0.48
KCNH2 Q12809 1/20 0.48
IKZF2 Q9UKS7 9/20 0.48
IKZF1 Q13422 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23357943 1.00 CRBN (0.50) CRBNGSPT1DDB1IKZF3CSNK1A1
SCHEMBL23358080 0.92 CRBN (0.52) CRBNGSPT1DDB1IKZF3CSNK1A1
SCHEMBL29944443 0.92 CRBN (0.52) CRBNGSPT1DDB1IKZF3CSNK1A1
SCHEMBL29944310 0.91 CRBN (0.50) CRBNGSPT1DDB1IKZF3CSNK1A1
SCHEMBL23357891 0.91 CRBN (0.50) CRBNGSPT1DDB1IKZF3CSNK1A1
SCHEMBL23358016 0.90 CRBN (0.53) CRBNGSPT1DDB1IKZF3CSNK1A1
SCHEMBL29944282 0.89 CRBN (0.56) CRBNGSPT1DDB1IKZF3CSNK1A1
SCHEMBL23358012 0.89 CRBN (0.56) CRBNGSPT1DDB1IKZF3CSNK1A1
SCHEMBL23357921 0.88 CRBN (0.52) CRBNGSPT1DDB1IKZF3CSNK1A1
SCHEMBL29944430 0.88 CRBN (0.52) CRBNGSPT1DDB1IKZF3CSNK1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4061812-B1 COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN BRISTOL MYERS SQUIBB CO (US) 2026-03-25 EP claimed
EP-4061812-B1 COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN BRISTOL MYERS SQUIBB CO (US) 2026-03-25 EP disclosed