⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628553 | 0.81 | — | — | |
| SCHEMBL21958211 | 0.78 | HDAC6 (0.33) | — | |
| SCHEMBL1244069 | 0.76 | HDAC8 (0.53) | — | |
| SCHEMBL7675118 | 0.76 | NPC1 (0.39) | — | |
| SCHEMBL11740436 | 0.71 | ALDH1A1 (0.49) | — | |
| SCHEMBL2058601 | 0.70 | — | — | |
| SCHEMBL11740193 | 0.68 | TAAR1 (0.48) | — | |
| SCHEMBL22006701 | 0.65 | ADRA1A (0.35) | — | |
| SCHEMBL21407447 | 0.65 | NOTUM (0.42) | — | |
| SCHEMBL543197 | 0.64 | CA1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190247371-A1 | METHODS FOR TREATING SMALL CELL LUNG CANCERS BY USING PHARMACEUTICAL COMPOSITIONS OR COMBINATIONS COMPRISING INDOLIZINO[6,7-B]INDOLE DERIVATIVES | ACADEMIA SINICA (TW) | 2019-08-15 | — | — | US | disclosed |
| EP-3515437-A1 | METHODS FOR TREATING SMALL CELL LUNG CANCERS BY USING PHARMACEUTICAL COMPOSITIONS OR COMBINATIONS COMPRISING INDOLIZINO (6,7-B) INDOLE DERIVATIVES | Academia Sinica (TW) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018057712-A1 | METHODS FOR TREATING SMALL CELL LUNG CANCERS BY USING PHARMACEUTICAL COMPOSITIONS OR COMBINATIONS COMPRISING INDOLIZINO (6,7-B) INDOLE DERIVATIVES | ACADEMIA SINICA (TW) | 2018-03-29 | — | — | WO | disclosed |
| CN-103626995-A | Preparation method for polyamides from glycol and diamine | DU PONT | 2014-03-12 | — | — | CN | disclosed |
| WO-2010049678-A2 | TREATMENT OF ENERGY UTILIZATION DISEASES | SUMMIT CORPORATION PLC (GB) | 2010-05-06 | — | — | WO | disclosed |
| WO-2010029313-A1 | ANTIINFECTIVE COMPOUNDS | SUMMIT CORPORATION PLC. (GB) | 2010-03-18 | — | — | WO | disclosed |
| US-4647576-A | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1987-03-03 | — | — | US | disclosed |
| EP-0179559-A2 | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1986-04-30 | — | — | EP | disclosed |