Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 11/20 | 0.39 |
| ▸ | GUCY1B1 | Q02153 | 11/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13733845 | 0.84 | GUCY1A1 (0.43) | GUCY1A1GUCY1B1HTR3A | |
| Acetic Acid SCHEMBL15065428 | 0.82 | GUCY1A1 (0.43) | GUCY1A1GUCY1B1HTR3A | |
| SCHEMBL19244706 | 0.82 | GRIN1 (0.34) | GUCY1A1GUCY1B1 | |
| SCHEMBL10071130 | 0.81 | GUCY1A1 (0.39) | GUCY1A1GUCY1B1 | |
| SCHEMBL17685043 | 0.80 | RET (0.39) | — | |
| SCHEMBL19244697 | 0.79 | PDE5A (0.33) | GUCY1A1GUCY1B1 | |
| SCHEMBL19244698 | 0.79 | GRIN1 (0.34) | GUCY1A1GUCY1B1 | |
| SCHEMBL15519699 | 0.78 | PDE5A (0.34) | GUCY1A1GUCY1B1 | |
| SCHEMBL19244708 | 0.78 | PDE5A (0.36) | GUCY1A1GUCY1B1 | |
| SCHEMBL19244701 | 0.78 | PTGDR2 (0.40) | GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699578-B1 | FLUOROALKYL-SUBSTITUTED PYRAZOLOPYRIDINES AND USE THEREOF | BAYER IP GMBH (DE) | 2016-04-20 | — | — | EP | disclosed |
| EP-2590987-B1 | CONDENSED 4-AMINOPYRIMIDINES AND THEIR USE AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE | BAYER IP GMBH (DE) | 2016-03-09 | — | — | EP | disclosed |
| EP-2699578-A1 | FLUOROALKYL-SUBSTITUTED PYRAZOLOPYRIDINES AND USE THEREOF | Bayer Intellectual Property GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| EP-2590987-A1 | RING-FUSED 4 -AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | Bayer Intellectual Property GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012143510-A1 | FLUOROALKYL-SUBSTITUTED PYRAZOLOPYRIDINES AND USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |
| WO-2012004259-A1 | RING-FUSED 4 -AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-12 | — | — | WO | disclosed |