Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 8/20 | 0.39 |
| ▸ | GUCY1B1 | Q02153 | 8/20 | 0.39 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.31 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL15065428 | 0.94 | GUCY1A1 (0.43) | GUCY1A1GUCY1B1 | |
| SCHEMBL15633063 | 0.87 | GUCY1A1 (0.38) | GUCY1A1GUCY1B1GUCY1B2GUCY1A2 | |
| SCHEMBL25975320 | 0.83 | GUCY1A1 (0.41) | GUCY1A1GUCY1B1GUCY1B2GUCY1A2 | |
| SCHEMBL326955 | 0.81 | GUCY1A1 (0.39) | GUCY1A1GUCY1B1 | |
| SCHEMBL10071129 | 0.81 | GUCY1A1 (0.42) | GUCY1A1GUCY1B1 | |
| SCHEMBL25977708 | 0.81 | GUCY1A1 (0.39) | GUCY1A1GUCY1B1GUCY1B2GUCY1A2 | |
| Hydrochloric Acid SCHEMBL20140172 | 0.80 | GUCY1A1 (0.41) | GUCY1A1GUCY1B1 | |
| SCHEMBL326986 | 0.79 | GUCY1A1 (0.38) | GUCY1A1GUCY1B1GUCY1B2GUCY1A2 | |
| SCHEMBL19158836 | 0.79 | SPR (0.42) | GUCY1A1GUCY1B1GUCY1B2GUCY1A2 | |
| SCHEMBL15944481 | 0.78 | GRIN1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230257398-A1 | PYRIMIDINE-BASED TRICYCLIC COMPOUND AND USE THEREOF | CHIA TAL TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2023-08-17 | — | — | US | disclosed |
| US-20230257398-A1 | PYRIMIDINE-BASED TRICYCLIC COMPOUND AND USE THEREOF | CHIA TAL TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2023-08-17 | — | — | US | disclosed |
| EP-2699578-B1 | FLUOROALKYL-SUBSTITUTED PYRAZOLOPYRIDINES AND USE THEREOF | BAYER IP GMBH (DE) | 2016-04-20 | — | — | EP | disclosed |
| EP-2590987-B1 | CONDENSED 4-AMINOPYRIMIDINES AND THEIR USE AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE | BAYER IP GMBH (DE) | 2016-03-09 | — | — | EP | disclosed |
| US-9090610-B2 | Fluoroalkyl-substituted pyrazolopyridines and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-07-28 | — | — | US | disclosed |
| US-9090610-B2 | Fluoroalkyl-substituted pyrazolopyridines and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-07-28 | — | — | US | disclosed |
| US-8765769-B2 | Ring-fused 4-aminopyrimidines and use thereof as stimulators of soluable guanylate cyclases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-07-01 | — | — | US | disclosed |
| US-8765769-B2 | Ring-fused 4-aminopyrimidines and use thereof as stimulators of soluable guanylate cyclases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-07-01 | — | — | US | disclosed |
| US-20130172372-A1 | RING-FUSED 4-AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
| US-20130172372-A1 | RING-FUSED 4-AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
| WO-2012004259-A1 | RING-FUSED 4 -AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172372-A1 | RING-FUSED 4-AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | GUCY1B1, GUCY1A2, GUCY1B2 | GUCY1A1 4/4885GUCY1B1 1/4885GUCY1B2 3/4885 |
| US-20230257398-A1 | PYRIMIDINE-BASED TRICYCLIC COMPOUND AND USE THEREOF | TYMP, TYMS, DPYD | GUCY1A1 2940/4885GUCY1B1 2239/4885GUCY1B2 1886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.