SCHEMBL3270022

SCHEMBL3270022

Cc1ccc(N2CCC(CCNC(=O)OCC(N)=O)CC2)nn1

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SCD O00767 6/20 0.43
TPSAB1 Q15661 1/20 0.41
TPSD1 Q9BZJ3 1/20 0.41
TPSG1 Q9NRR2 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
SIRT2 Q8IXJ6 2/20 0.40
SIRT1 Q96EB6 2/20 0.40
SIRT3 Q9NTG7 2/20 0.40
KDM4E B2RXH2 1/20 0.39
CHRM4 P08173 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3266159 0.89 TPSAB1 (0.41) SCDTPSAB1TPSD1TPSG1MEN1
SCHEMBL3265544 0.89 MEN1 (0.42) TPSAB1TPSD1TPSG1MEN1KMT2A
SCHEMBL3266210 0.85 CHRM4 (0.45) TPSAB1TPSD1TPSG1SIRT2SIRT1
SCHEMBL3268959 0.85 SCD (0.42) SCDMEN1KMT2ACHRM4
SCHEMBL1728820 0.83 SCD (0.49) SCDKDM4ECHRM4
SCHEMBL3266141 0.82 HRH4 (0.44) TPSAB1TPSD1TPSG1SMN1; SMN2SIRT2
SCHEMBL3265639 0.82 HRH3 (0.44) KMT2ASMN1; SMN2SIRT2SIRT1SIRT3
SCHEMBL3266256 0.81 DEGS1 (0.48) KDM4ECHRM4
SCHEMBL3269077 0.81 CHRM4 (0.49) TPSAB1TPSD1TPSG1KMT2ASIRT2
SCHEMBL3266214 0.81 CHRM4 (0.43) KMT2ASMN1; SMN2SIRT2SIRT1SIRT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120004207-A1 THERAPEUTIC USES OF DERIVATIVES OF PIPERIDINYL-AND PIPERIDINYL-ALKYL CARBAMATES SANOFI-AVENTIS (FR) 2012-01-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120004207-A1 THERAPEUTIC USES OF DERIVATIVES OF PIPERIDINYL-AND PIPERIDINYL-ALKYL CARBAMATES CLCN2, CLIC1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 SCD 4356/4885TPSAB1 3455/4885TPSD1 3757/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.