Temozolomide

Temozolomide

SCHEMBL3270220

Cn1nnc2c(C(N)=O)ncn2c1=O.Cn1nnc2c(C(N)=O)ncn2c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 1.00
PABPC1 P11940 1/20 1.00
KMT2A Q03164 1/20 1.00
CA12 O43570 3/20 0.54
CA1 P00915 3/20 0.54
CA2 P00918 3/20 0.54
CA9 Q16790 3/20 0.54
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
HCAR3 P49019 1/20 0.33
APOBEC3A P31941 1/20 0.30
APOBEC3G Q9HC16 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Temozolomide SCHEMBL3739 1.00 MEN1 (1.00) MEN1PABPC1KMT2ACA12CA1
Temozolomide SCHEMBL4746638 0.98 MEN1 (0.97) MEN1PABPC1KMT2ACA12CA1
Temozolomide SCHEMBL3784250 0.98 MEN1 (0.97) MEN1PABPC1KMT2ACA12CA1
Temozolomide SCHEMBL28275477 0.98 MEN1 (0.97) MEN1PABPC1KMT2ACA12CA1
Temozolomide SCHEMBL1534013 0.98 MEN1 (0.97) MEN1PABPC1KMT2ACA12CA1
Temozolomide SCHEMBL27721442 0.94 MEN1 (0.89) MEN1PABPC1KMT2ACA12CA1
Temozolomide SCHEMBL16227379 0.91 MEN1 (0.82) MEN1PABPC1KMT2ACA12CA1
Temozolomide SCHEMBL10168201 0.90 MEN1 (0.81) MEN1PABPC1KMT2ACA12CA1
Altretamine SCHEMBL27875070 0.89 KMT2A (0.80) MEN1PABPC1KMT2ACA12CA1
Temozolomide SCHEMBL4444959 0.88 MEN1 (0.78) MEN1PABPC1KMT2ACA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019024784-A1 FATTY ACID CONJUGATED NANOPARTICLES AND USES THEREOF THE CHINESE UNIVERSITY OF HONG KONG (CN) 2019-02-07 WO claimed
US-20190029970-A1 FATTY ACID CONJUGATED NANOPARTICLES AND USES THEREOF THE CHINESE UNIVERSITY OF HONG KONG (CN) 2019-01-31 US claimed
WO-2007149103-A2 VASCULAR TISSUE ENHANCEMENT AND SELECTIVE DESTRUCTION OF CANCEROUS CELLULAR TISSUE KAISER DANIEL E (US) 2007-12-27 WO claimed
CN-112262156-B Anti-HER 2 antibodies 新加坡科技研究局 2024-07-05 CN disclosed
US-20230181534-A1 USE OF A PROTEASOME INHIBITOR FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) CANCERS CELGENE INT II SARL (CH) 2023-06-15 US disclosed
EP-3675838-A1 LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS Puretecch LYT, Inc. (US) 2020-07-08 EP disclosed
US-10683338-B2 Single-chain TL1A receptor agonist proteins APOGENIX AG (DE) 2020-06-16 US disclosed
US-20200085789-A1 USE OF A PROTEASOME INHIBITOR FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) CANCERS CELGENE INT II SARL (CH) 2020-03-19 US disclosed
EP-3080341-B1 METHODS FOR DETERMINING AND/OR ISOLATING CELLS SUCH AS CIRCULATING CANCER OR FETAL CELLS ANALIZA INC (US) 2020-02-12 EP disclosed
WO-2019046491-A1 LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS ARIYA THERAPEUTICS, INC. (US) 2019-03-07 WO disclosed
WO-2019040724-A1 SMALL MOLECULE INHIBITORS OF MYC AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2019-02-28 WO disclosed
EP-2970965-A2 DNAI FOR THE MODULATION OF GENES Pronai Therapeutics, Inc. (US) 2016-01-20 EP disclosed
US-20150160246-A1 DEVICES AND METHODS FOR DETERMINING AND/OR ISOLATING CELLS SUCH AS CIRCULATING CANCER OR FETAL CELLS ANALIZA, INC. (US) 2015-06-11 US disclosed
WO-2014144942-A2 DNAI FOR THE MODULATION OF GENES PRONAI THERAPEUTICS, INC. (US) 2014-09-18 WO disclosed
WO-2013119923-A1 DIFFERENT STATES OF CANCER STEM CELLS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2013-08-15 WO disclosed
CN-102497864-A Sigma ligands for the prevention or treatment of pain induced by chemotherapy ESTEVE LABOR DR 2012-06-13 CN disclosed
EP-1934224-B1 PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS FOR THE TREATMENT OF CANCER SCHERING CORP (US) 2010-06-09 EP disclosed
WO-2007139556-A1 COMBINATION OF CHEMOTHERAPEUTIC COMPOUNDS FOR TREATING CANCER REATA PHARMACEUTICALS, INC. (US) 2007-12-06 WO disclosed
EP-1549742-A1 METHOD FOR SELECTION OF COMPOUNDS WHICH INHIBIT CLONAL CELL GROWTH AND USE THEREOF Tjötta, Enok (NO) 2005-07-06 EP disclosed
WO-2004055175-A1 METHOD FOR SELECTION OF COMPOUNDS WHICH INHIBIT CLONAL CELL GROWTH AND USE THEREOF TJOETTA ENOK (NO) 2004-07-01 WO disclosed