Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.87 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.87 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | EP300 | Q09472 | 1/20 | 0.54 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21965004 | 0.93 | CYP3A4 (0.81) | CYP3A4CYP2C19HPGDMEN1KMT2A | |
| SCHEMBL3272757 | 0.91 | CYP2C19 (0.73) | CYP3A4CYP2C19HPGDMEN1KMT2A | |
| SCHEMBL21961586 | 0.81 | CYP3A4 (0.80) | CYP3A4CYP2C19HPGDMEN1KMT2A | |
| SCHEMBL21965003 | 0.81 | CYP3A4 (0.75) | CYP3A4CYP2C19HPGDMEN1KMT2A | |
| SCHEMBL31525688 | 0.81 | ALDH1A1 (0.60) | CYP3A4CYP2C19HPGDMEN1KMT2A | |
| SCHEMBL1466916 | 0.81 | POLB (0.62) | CYP3A4CYP2C19HPGDMEN1KMT2A | |
| SCHEMBL15075120 | 0.80 | HPGD (1.00) | CYP3A4CYP2C19HPGDMEN1KMT2A | |
| SCHEMBL21961616 | 0.80 | CYP3A4 (0.78) | CYP3A4CYP2C19HPGDMEN1KMT2A | |
| SCHEMBL21964271 | 0.80 | CYP3A4 (0.78) | CYP3A4CYP2C19HPGDMEN1KMT2A | |
| SCHEMBL18390063 | 0.80 | CYP3A4 (0.65) | CYP3A4CYP2C19MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747210-B1 | 3- OR 4-MONOSUBSTITUTED PHENOL AND THIOPHENOL DERIVATIVES USEFUL AS H3 LIGANDS | WARNER LAMBERT CO (US) | 2010-06-30 | — | — | EP | disclosed |
| US-7456164-B2 | Useful for treatment of H3-related diseases such as neurologic disorders, or inflammatory, respiratory and allergic diseases, disorders and conditions; for example, 4-[4-(1-isopropylpiperidin-4-yloxy)phenyl]tetrahydropyran-4-carbonitrile; well absorbed from gastrointestinal tract, metabolically stable | PFIZER, INC (US) | 2008-11-25 | — | — | US | disclosed |
| US-20050267095-A1 | 3- or 4-monosubstituted phenol and thiophenol derivatives useful as H3 ligands | ZIARCO INC. | 2005-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267095-A1 | 3- or 4-monosubstituted phenol and thiophenol derivatives useful as H3 ligands | HRH4, HRH3, TLR4 | CYP3A4 104/4885CYP2C19 854/4885HPGD 970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.