Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.62 |
| ▸ | GUCY1A1 | Q02108 | 9/20 | 0.62 |
| ▸ | GUCY1B1 | Q02153 | 9/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL325995 | 0.86 | PDE5A (0.59) | PDE5AGUCY1A1GUCY1B1ADORA3KCNH2 | |
| SCHEMBL9913955 | 0.85 | PDE5A (0.64) | PDE5A | |
| SCHEMBL9913986 | 0.85 | PDE5A (0.63) | PDE5A | |
| SCHEMBL9913952 | 0.85 | PDE5A (0.82) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL9913975 | 0.84 | PDE5A (0.57) | PDE5AGUCY1A1GUCY1B1ADORA3KCNH2 | |
| SCHEMBL174664 | 0.83 | GUCY1A1 (0.59) | PDE5AGUCY1A1GUCY1B1ADORA3KCNH2 | |
| SCHEMBL174847 | 0.83 | ADORA3 (0.67) | PDE5AGUCY1A1GUCY1B1ADORA3KCNH2 | |
| SCHEMBL19006325 | 0.83 | PDE5A (0.62) | PDE5AGUCY1A1GUCY1B1ADORA3KCNH2 | |
| Hydrochloric Acid SCHEMBL15732830 | 0.83 | GUCY1A1 (0.58) | PDE5AGUCY1A1GUCY1B1ADORA3KCNH2 | |
| Hydrochloric Acid SCHEMBL1930775 | 0.82 | ADORA3 (0.66) | PDE5AGUCY1A1GUCY1B1ADORA3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590987-B1 | CONDENSED 4-AMINOPYRIMIDINES AND THEIR USE AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE | BAYER IP GMBH (DE) | 2016-03-09 | — | — | EP | disclosed |
| US-8765769-B2 | Ring-fused 4-aminopyrimidines and use thereof as stimulators of soluable guanylate cyclases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-07-01 | — | — | US | disclosed |
| US-8765769-B2 | Ring-fused 4-aminopyrimidines and use thereof as stimulators of soluable guanylate cyclases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-07-01 | — | — | US | disclosed |
| US-8765769-B2 | Ring-fused 4-aminopyrimidines and use thereof as stimulators of soluable guanylate cyclases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-07-01 | — | — | US | disclosed |
| US-20130172372-A1 | RING-FUSED 4-AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
| US-20130172372-A1 | RING-FUSED 4-AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
| US-20130172372-A1 | RING-FUSED 4-AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
| EP-2590987-A1 | RING-FUSED 4 -AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | Bayer Intellectual Property GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004259-A1 | RING-FUSED 4 -AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-12 | — | — | WO | disclosed |
| WO-2012004259-A1 | RING-FUSED 4 -AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172372-A1 | RING-FUSED 4-AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | GUCY1B1, GUCY1A2, GUCY1B2 | PDE5A 15/4885GUCY1A1 4/4885GUCY1B1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.