Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4864274 | 0.90 | MIF (0.45) | MIFKMT2AMEN1PDE5AALDH1A1 | |
| SCHEMBL4865701 | 0.84 | EGFR (0.55) | MIFKMT2AMEN1PDE5AALDH1A1 | |
| SCHEMBL3277558 | 0.81 | POLB (0.41) | MIFKMT2AMEN1PDE5AALDH1A1 | |
| SCHEMBL13382196 | 0.81 | BAZ2B (0.52) | MIFKMT2AMEN1PDE5AALDH1A1 | |
| SCHEMBL27628762 | 0.79 | MIF (0.42) | MIFKMT2AMEN1PDE5AALDH1A1 | |
| SCHEMBL4868073 | 0.78 | TGFBR1 (0.43) | TGFBR1TGFBR2CCR1CCR8 | |
| SCHEMBL7665680 | 0.77 | EGFR (0.61) | MIFKMT2AMEN1PDE5AALDH1A1 | |
| SCHEMBL4868193 | 0.77 | TGFBR1 (0.41) | MIFKMT2AMEN1PDE5AALDH1A1 | |
| SCHEMBL4865571 | 0.77 | BAZ2B (0.44) | TGFBR1TGFBR2BAZ2BBAZ2A | |
| SCHEMBL13105301 | 0.76 | EGFR (0.48) | MIFKMT2AMEN1PDE5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7691865-B2 | Pyrazolopyridines and methods of making and using the same | BIOGEN IDEC MA INC. (US) | 2010-04-06 | — | — | US | disclosed |
| EP-1551398-A4 | PYRAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC INC (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20060106033-A1 | Pyrazolopyridines and methods of making and using the same | BIOGEN IDEC MA INC. | 2006-05-18 | — | — | US | disclosed |
| EP-1551398-A1 | PYRAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | Biogen Idec MA Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004022054-A1 | PYRAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2004-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106033-A1 | Pyrazolopyridines and methods of making and using the same | ALK, ACVR1, ACVRL1 | MIF 1257/4885KMT2A 1246/4885MEN1 3789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.