Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 6/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL3272884 | 1.00 | ACHE (0.43) | ACHEHDAC8MEN1NPC1RAB9A | |
| SCHEMBL6478280 | 0.99 | HDAC8 (0.44) | ACHEHDAC8MEN1NPC1RAB9A | |
| SCHEMBL6478283 | 0.99 | HDAC8 (0.44) | ACHEHDAC8MEN1NPC1RAB9A | |
| Iodide SCHEMBL3271941 | 0.76 | RAB9A (0.60) | ACHEMEN1NPC1RAB9AKMT2A | |
| Iodide SCHEMBL3271943 | 0.76 | RAB9A (0.60) | ACHEMEN1NPC1RAB9AKMT2A | |
| SCHEMBL3276498 | 0.75 | IP6K1 (0.56) | MEN1NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL3276501 | 0.75 | IP6K1 (0.56) | MEN1NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL6487272 | 0.75 | RAB9A (0.57) | ACHEMEN1NPC1RAB9AKMT2A | |
| SCHEMBL6487275 | 0.75 | RAB9A (0.57) | ACHEMEN1NPC1RAB9AKMT2A | |
| Iodide SCHEMBL29604021 | 0.73 | ACHE (0.39) | ACHEMEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7691624-B2 | Cancer cell detecting devices | ACADEMIA SINICA (TW) | 2010-04-06 | — | — | US | disclosed |
| US-20070098233-A1 | Cancer cell detecting devices | ACADEMIA SINICA | 2007-05-03 | — | — | US | disclosed |
| US-6979738-B2 | for human telomeres/telomerases; drug screening | ACADEMIA SINICA (TW) | 2005-12-27 | — | — | US | disclosed |
| US-20050249669-A1 | Quadruplex stabilizer | ACADEMIA SINICA | 2005-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050249669-A1 | Quadruplex stabilizer | HNRNPA3, HNRNPR, ANXA3 | ACHE 4711/4885HDAC8 2309/4885MEN1 749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.