Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CASP3 | P42574 | 3/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | RORA | P35398 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11238457 | 0.66 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2PKMNFKB1 | |
| SCHEMBL27723986 | 0.65 | NPC1 (0.52) | RAB9ANPC1SMN1; SMN2PKMNFKB1 | |
| SCHEMBL7621355 | 0.64 | RARA (0.82) | KMT2AMEN1ALDH1A1RORARORC | |
| SCHEMBL8522186 | 0.64 | RARA (0.68) | RAB9ANPC1SMN1; SMN2PKMNFKB1 | |
| SCHEMBL25206719 | 0.64 | NPC1 (0.60) | RAB9ANPC1SMN1; SMN2PKMNFKB1 | |
| SCHEMBL4450882 | 0.64 | NPC1 (0.50) | RAB9ANPC1SMN1; SMN2PKMNFKB1 | |
| SCHEMBL6108965 | 0.64 | NPC1 (0.56) | RAB9ANPC1SMN1; SMN2PKMNFKB1 | |
| SCHEMBL1315526 | 0.63 | PTPN1 (0.87) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL2371980 | 0.63 | BACE1 (0.36) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL8374911 | 0.62 | HDAC1 (0.85) | RAB9ANPC1SMN1; SMN2PKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426447-B2 | Spiro-tricyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2013-04-23 | — | — | US | disclosed |
| US-20100087429-A1 | SPIRO-TRICYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087429-A1 | SPIRO-TRICYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | BACE1, BACE2, APP | RAB9A 1822/4885NPC1 1054/4885SMN1; SMN2 2585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.