Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ARG1 | P05089 | 1/20 | 0.35 |
| ▸ | ARG2 | P78540 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27055108 | 0.87 | PAOX (0.41) | ARG1ARG2ALDH1A1EPHX2MAPT | |
| SCHEMBL12014400 | 0.84 | ALDH1A1 (0.48) | SMN1; SMN2LMNAHSD17B10ALDH1A1TSHR | |
| SCHEMBL1128504 | 0.82 | TP53 (0.48) | SMN1; SMN2KDM4ELMNAALDH1A1TSHR | |
| SCHEMBL12936833 | 0.82 | PLA2G10 (0.37) | SMN1; SMN2KDM4ELMNAALDH1A1PREP | |
| SCHEMBL12014399 | 0.82 | ALDH1A1 (0.52) | SMN1; SMN2LMNAHSD17B10ALDH1A1TSHR | |
| SCHEMBL66203 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4ELMNAHSD17B10ALDH1A1 | |
| SCHEMBL6600492 | 0.79 | MEN1 (0.41) | SMN1; SMN2LMNAHSD17B10ALDH1A1TSHR | |
| SCHEMBL18729437 | 0.79 | MEN1 (0.41) | SMN1; SMN2LMNAHSD17B10ALDH1A1TSHR | |
| SCHEMBL17025689 | 0.79 | SMN1; SMN2 (0.37) | SMN1; SMN2KDM4EALDH1A1TSHRTP53 | |
| SCHEMBL1127834 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAALDH1A1MAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590954-A1 | BISARYL (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS | ABBVIE B.V. (NL) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004375-A1 | BISARYL (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS | ABBOTT HEALTHCARE PRODUCTS B.V. (NL) | 2012-01-12 | — | — | WO | disclosed |