Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 5/20 | 0.53 |
| ▸ | FLT4 | P35916 | 5/20 | 0.53 |
| ▸ | KDR | P35968 | 5/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3273588 | 1.00 | FLT1 (0.53) | FLT1FLT4KDREGFRTRPA1 | |
| SCHEMBL3273574 | 0.88 | EGFR (0.46) | EGFRTRPA1KCNK2MEN1KMT2A | |
| SCHEMBL3273565 | 0.88 | EGFR (0.46) | EGFRTRPA1KCNK2MEN1KMT2A | |
| SCHEMBL3278122 | 0.85 | EGFR (0.52) | EGFRTRPA1MEN1KMT2AALDH1A1 | |
| SCHEMBL3278130 | 0.85 | EGFR (0.52) | EGFRTRPA1MEN1KMT2AALDH1A1 | |
| SCHEMBL3274042 | 0.84 | TRPA1 (0.64) | EGFRTRPA1KCNK2MEN1KMT2A | |
| SCHEMBL3274049 | 0.84 | TRPA1 (0.64) | EGFRTRPA1KCNK2MEN1KMT2A | |
| SCHEMBL3273494 | 0.81 | EGFR (0.46) | EGFRTRPA1KCNK2MEN1KMT2A | |
| SCHEMBL3273489 | 0.81 | EGFR (0.46) | EGFRTRPA1KCNK2MEN1KMT2A | |
| SCHEMBL3280717 | 0.78 | EGFR (0.50) | EGFRTRPA1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-08 | — | — | US | claimed |
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-08 | — | — | US | disclosed |
| EP-2121569-A2 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008074755-A2 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | TRPV1, TRPA1, TRPM8 | FLT1 4171/4885FLT4 3811/4885KDR 2970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.