Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.91 |
| ▸ | ARG2 | P78540 | 4/20 | 0.55 |
| ▸ | ARG1 | P05089 | 3/20 | 0.55 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.54 |
| ▸ | NOS2 | P35228 | 5/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | NOS1 | P29475 | 3/20 | 0.48 |
| ▸ | NOS3 | P29474 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GRM8 | O00222 | 1/20 | 0.48 |
| ▸ | GRM6 | O15303 | 1/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL3275069 | 1.00 | GSR (0.91) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL28262858 | 0.95 | GSR (0.91) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL456381 | 0.95 | GSR (1.00) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL7343 | 0.95 | GSR (1.00) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL3359527 | 0.95 | GSR (1.00) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL1000151 | 0.95 | GSR (1.00) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL20362357 | 0.95 | GSR (1.00) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL9439278 | 0.95 | GSR (1.00) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL8613373 | 0.95 | GSR (1.00) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL1645 | 0.95 | GSR (1.00) | GSRARG2ARG1RNPEPNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110776508-B | BRD4 inhibitor and preparation method and application thereof | 海创药业股份有限公司 | 2021-07-16 | — | — | CN | disclosed |
| CN-110776508-A | BRD4 inhibitor and preparation method and application thereof | 成都海创药业有限公司 | 2020-02-11 | — | — | CN | disclosed |
| US-8334403-B1 | C-lysine conjugates as pH-controlled, light-activated reagents for double stranded DNA cleavage and associated methods | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2012-12-18 | — | — | US | disclosed |
| US-8242307-B1 | Site-specific cleavage of nucleic acids by photoreactive conjugates | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2012-08-14 | — | — | US | disclosed |
| US-7695912-B1 | Site-specific cleavage of nucleic acids by photoreactive conjugates | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2010-04-13 | — | — | US | disclosed |