Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.45 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3271587 | 1.00 | LCK (0.61) | LCKSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL13400114 | 1.00 | LCK (0.61) | LCKSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL3279406 | 1.00 | LCK (0.61) | LCKSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL3272471 | 1.00 | LCK (0.61) | LCKSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL13400113 | 1.00 | LCK (0.61) | LCKSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL13400095 | 1.00 | LCK (0.61) | LCKSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL7506131 | 0.86 | SMN1; SMN2 (0.54) | LCKSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL13059807 | 0.86 | SMN1; SMN2 (0.55) | LCKSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL17084106 | 0.86 | SMN1; SMN2 (0.55) | LCKSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL16980450 | 0.86 | SMN1; SMN2 (0.55) | LCKSMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7692019-B2 | Methods for the stereoselective synthesis of substituted piperidines | SEPRACOR INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-7692019-B2 | Methods for the stereoselective synthesis of substituted piperidines | SEPRACOR INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-7692019-B2 | Methods for the stereoselective synthesis of substituted piperidines | SEPRACOR INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-20060211864-A1 | Methods for the stereoselective synthesis of substituted piperidines | AQUILA BRIAN M | 2006-09-21 | — | — | US | disclosed |
| US-7005524-B2 | Methods for the stereoselective synthesis of substituted piperidines | SEPRACOR INC. (US) | 2006-02-28 | — | — | US | disclosed |
| US-20040235893-A1 | Methods for the stereoselective synthesis of substituted piperidines | AQUILA BRIAN M (US) | 2004-11-25 | — | — | US | disclosed |
| US-6703508-B2 | ANALGESICS | SEPRACOR, INC. | 2004-03-09 | — | — | US | disclosed |
| US-20020177721-A1 | Methods for the stereoselective synthesis of substituted piperidines | SEPRACOR INC. | 2002-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235893-A1 | Methods for the stereoselective synthesis of substituted piperidines | OPRK1, OPRL1, HTR5A | LCK 2312/4885SMN1; SMN2 1250/4885NPC1 1093/4885 |
| US-20060211864-A1 | Methods for the stereoselective synthesis of substituted piperidines | OPRK1, OPRL1, HTR5A | LCK 2312/4885SMN1; SMN2 1250/4885NPC1 1093/4885 |
| US-20020177721-A1 | Methods for the stereoselective synthesis of substituted piperidines | OPRK1, OPRL1, HTR5A | LCK 2312/4885SMN1; SMN2 1250/4885NPC1 1093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.