Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 11/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.80 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.80 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.80 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.76 |
| ▸ | PGR | P06401 | 2/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | GC | P02774 | 1/20 | 0.76 |
| ▸ | RXRA | P19793 | 1/20 | 0.76 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.76 |
| ▸ | CNR1 | P21554 | 1/20 | 0.76 |
| ▸ | HTR2C | P28335 | 1/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.76 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.76 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tacalcitol SCHEMBL5082357 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL6932330 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL3278786 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL5433654 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL3609295 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL5444609 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL24066858 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL2130976 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL21836181 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL5444615 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047671-B1 | METHOD OF PREPARATION OF CHOLECALCIFEROL DERIVATIVES AND NEW INTERMEDIATE COMPOUNDS | INST FARMACEUTYCZNY (PL) | 2003-12-10 | — | — | EP | claimed |
| US-5804573-A | WITH ADDITIVE ANTIOXIDANT, POLYOXYALKYL STABILIZER, CARRIER | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 1998-09-08 | — | — | US | claimed |
| US-5700790-A | Prevention and treatment of myocardial failure | BONE CARE INTERNATIONAL, INC. (US) | 1997-12-23 | — | — | US | claimed |
| EP-0588539-B1 | Stabilized pharmaceutical compositions containing derivatives of vitamins D2 and D3 | TEVA PHARMA (IL) | 1997-02-05 | — | — | EP | claimed |
| US-5565442-A | DISSOLVING IN SOLVENT WITH ANTIOXIDANT AND POLYOXYALKYL STABILIZER; COMPOSITING WITH CARRIER OR EXCIPIENT TO IMPART SOLID CHARACTERISTICS; DESOLVENTIZING; USEFUL IN CONDITIONS OF VITAMIN D DEFICIENCY | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 1996-10-15 | — | — | US | claimed |
| EP-0680329-A4 | PREVENTION AND TREATMENT OF MYOCARDIAL FAILURE. | LUNAR CORP (US) | 1996-05-29 | — | — | EP | claimed |
| EP-0413828-B1 | SOLID PREPARATION OF ACTIVE VITAMIN D3 HAVING IMPROVED STABILITY | TEIJIN LTD (JP) | 1996-04-17 | — | — | EP | claimed |
| EP-0680329-A1 | PREVENTION AND TREATMENT OF MYOCARDIAL FAILURE | BONE CARE INTERNATIONAL, INC. (US) | 1995-11-08 | — | — | EP | claimed |
| US-5350745-A | Treatment of myocardial failure | LUNAR CORPORATION (US) | 1994-09-27 | — | — | US | claimed |
| WO-1994016711-A1 | PREVENTION AND TREATMENT OF MYOCARDIAL FAILURE | LUNAR CORPORATION (US) | 1994-08-04 | — | — | WO | claimed |
| EP-0588539-A1 | Stabilized pharmaceutical compositions containing derivatives of vitamins D2 and D3 | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1994-03-23 | — | — | EP | claimed |
| EP-0390930-B1 | STABLE AQUEOUS PREPARATION OF ACTIVE VITAMIN D 3 | TEIJIN LIMITED (JP) | 1993-03-03 | — | — | EP | claimed |
| US-5182274-A | Nonionic surfactant, citric acid or tartaric acid chelating agent | TEIJIN LIMITED (JP) | 1993-01-26 | — | — | US | claimed |
| EP-0413828-A1 | SOLID PREPARATION OF ACTIVE VITAMIN D3 HAVING IMPROVED STABILITY | TEIJIN LIMITED (JP) | 1991-02-27 | — | — | EP | claimed |
| EP-0390930-A1 | STABLE AQUEOUS PREPARATION OF ACTIVE VITAMIN D 3 | TEIJIN LIMITED (JP) | 1990-10-10 | — | — | EP | claimed |
| EP-0177920-B1 | PHARMACEUTICAL COMPOSITION FOR EXTERNAL USE CONTAINING ACTIVE TYPE VITAM D3 | TEIJIN LIMITED (JP) | 1990-09-12 | — | — | EP | claimed |
| US-4948788-A | FREEZE DRIED ACTIVE MATERIAL AND AN EXCIPIENT; HEAT RESISTANCE PHOTOSTABILITY; STORAGE STABILITY | TEIJIN LIMITED (JP) | 1990-08-14 | — | — | US | claimed |
| US-4871723-A | 1A,24-DIHYDROXYCHOLECALCIFEROL; OILY CARRIER; FATTY ACID ESTER , FATTY ALCOHOL OR PROPYLENE CARBONATE AS SOLVENT | TEIJIN, LIMITED (JP) | 1989-10-03 | — | — | US | claimed |
| US-4594340-A | Antitumor agent | HOFFMANN-LA ROCHE INC. (US) | 1986-06-10 | — | — | US | claimed |
| US-4364941-A | ANALOGS OF VITAMIN D3 | TEIJIN LIMITED (JP) | 1982-12-21 | — | — | US | claimed |