Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 11/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.80 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.80 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.80 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.76 |
| ▸ | PGR | P06401 | 2/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | GC | P02774 | 1/20 | 0.76 |
| ▸ | RXRA | P19793 | 1/20 | 0.76 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.76 |
| ▸ | CNR1 | P21554 | 1/20 | 0.76 |
| ▸ | HTR2C | P28335 | 1/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.76 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.76 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tacalcitol SCHEMBL5082357 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL6932330 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL5433654 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL3609295 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL5444609 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL24066858 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL3278784 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL2130976 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL21836181 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT | |
| Tacalcitol SCHEMBL5444615 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2AGTR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 120 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165061-B1 | USE OF COMPOUND PREPARATION MADE OF VITAMIN D METABOLITES OR VITAMIN D ANALOGUES AND PARTIAL ESTROGEN AGONISTS FOR TREATING OSTEOPOROSIS | SCHERING AG (DE) | 2005-10-19 | — | — | EP | claimed |
| EP-0567352-B1 | Use of 1-alpha,24(R)-dihydroxy-22(E)-dehydro-vitamin D3 for the manufacture of a medicament for the treatment of osteoporosis | WISCONSIN ALUMNI RES FOUND (US) | 1996-03-13 | — | — | EP | claimed |
| EP-0567352-A1 | Use of 1-alpha,24(R)-dihydroxy-22(E)-dehydro-vitamin D3 for the manufacture of a medicament for the treatment of osteoporosis | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1993-10-27 | — | — | EP | claimed |
| EP-0177920-B1 | PHARMACEUTICAL COMPOSITION FOR EXTERNAL USE CONTAINING ACTIVE TYPE VITAM D3 | TEIJIN LIMITED (JP) | 1990-09-12 | — | — | EP | claimed |
| US-4594340-A | Antitumor agent | HOFFMANN-LA ROCHE INC. (US) | 1986-06-10 | — | — | US | claimed |
| US-4364941-A | ANALOGS OF VITAMIN D3 | TEIJIN LIMITED (JP) | 1982-12-21 | — | — | US | claimed |
| US-4305935-A | VITAMIN D3 DERIVATIVE AND ACETYLSALICYLIC ACID USEFUL AGAINST THE DISEASES CAUSED BY VITAMIN D DEFICIENCY | TEIJIN LIMITED (JP) | 1981-12-15 | — | — | US | claimed |
| US-4022891-A | Novel 1α,24-dihydroxycholecalciferol compositions, novel precursors thereof, and processes for preparing them | TEIJIN LIMITED (JA) | 1977-05-10 | — | — | US | claimed |
| JP-62026223-A | — | — | None | — | — | JP | disclosed |
| JP-7196515-A | — | — | None | — | — | JP | disclosed |
| JP-6024992-A | — | — | None | — | — | JP | disclosed |
| JP-7196514-A | — | — | None | — | — | JP | disclosed |
| JP-59186956-A | — | — | None | — | — | JP | disclosed |
| JP-7242550-A | — | — | None | — | — | JP | disclosed |
| EP-0177920-A2 | Pharmaceutical composition for external use containing active type vitam D3 | TEIJIN LIMITED (JP) | 1986-04-16 | — | — | EP | disclosed |
| EP-0081793-B1 | NOVEL VITAMIN D3 DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Chugai Seiyaku Kabushiki Kaisha (JP) | 1986-04-09 | — | — | EP | disclosed |
| JP-S59186956-A | 24-HYDROXY-25-DEHYDROVITAMIN D3, ITS PRODUCTION AND CALCIUM REGULATING AGENT CONTAINING THE SAME AS ACTIVE CONSTITUENT | TEIJIN LTD | 1984-10-23 | — | — | JP | disclosed |
| US-4341774-A | Method for suppressing abnormal rise in immunological function and agent useful therefor | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1982-07-27 | — | — | US | disclosed |
| US-4305935-A | VITAMIN D3 DERIVATIVE AND ACETYLSALICYLIC ACID USEFUL AGAINST THE DISEASES CAUSED BY VITAMIN D DEFICIENCY | TEIJIN LIMITED (JP) | 1981-12-15 | — | — | US | disclosed |
| US-4022891-A | Novel 1α,24-dihydroxycholecalciferol compositions, novel precursors thereof, and processes for preparing them | TEIJIN LIMITED (JA) | 1977-05-10 | — | — | US | disclosed |