⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12179431 | 0.66 | — | — | |
| SCHEMBL21648156 | 0.54 | — | — | |
| SCHEMBL895220 | 0.46 | — | — | |
| SCHEMBL8758 | 0.46 | — | — | |
| SCHEMBL19280 | 0.45 | — | — | |
| SCHEMBL12344959 | 0.43 | ACHE (0.91) | — | |
| O-Xylene SCHEMBL8216257 | 0.43 | TSHR (1.00) | — | |
| O-Xylene SCHEMBL11034038 | 0.43 | TSHR (1.00) | — | |
| O-Xylene SCHEMBL170581 | 0.43 | TSHR (1.00) | — | |
| O-Xylene SCHEMBL10522915 | 0.43 | TSHR (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220000900-A1 | Oligonucleotide Analogues Incorporating 5-Aza-Cytosine Therein | ASTEX PHARMACEUTICALS INC (US) | 2022-01-06 | — | — | US | disclosed |
| US-10941399-B2 | Methods and compositions for gene-specific demethylation by DNA methyltransferase (DNMT)-RNA interaction | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2021-03-09 | — | — | US | disclosed |
| US-10933079-B2 | Oligonucleotide analogues incorporating 5-aza-cytosine therein | ASTEX PHARMACEUTICALS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-20200215092-A1 | Oligonucleotide Analogues Incorporating 5-Aza-Cytosine Therein | ASTEX PHARMACEUTICALS, INC. | 2020-07-09 | — | — | US | disclosed |
| US-20200063130-A1 | CHIMERIC RNA OLIGONUCLEOTIDES AND USES THEREOF | Università Cattolica del Sacro Cuore (IT) | 2020-02-27 | — | — | US | disclosed |
| US-10456415-B2 | Oligonucleotide analogues incorporating 5-aza-cytosine therein | ASTEX PHARMACEUTICALS, INC. (US) | 2019-10-29 | — | — | US | disclosed |
| US-20170035794-A1 | Oligonucleotide Analogues Incorporating 5-Aza-Cytosine Therein | ASTEX PHARMACEUTICALS, INC. | 2017-02-09 | — | — | US | disclosed |
| US-9480698-B2 | Oligonucleotide analogues incorporating 5-aza-cytosine therein | ASTEX PHARMACEUTICALS, INC. (US) | 2016-11-01 | — | — | US | disclosed |
| US-9358248-B2 | Oligonucleotide analogues incorporating 5-aza-cytosine therein | ASTEX PHARMACEUTICALS, INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-20160130296-A1 | Oligonucleotide Analogues Incorporating 5-Aza-Cytosine Therein | ASTEX PHARMACEUTICALS, INC. | 2016-05-12 | — | — | US | disclosed |
| EP-1943264-B1 | OLIGONUCLEOTIDE ANALOGUES INCORPORATING 5-AZA-CYTOSINE THEREIN | ASTEX PHARMACEUTICALS INC (US) | 2015-07-29 | — | — | EP | disclosed |
| US-20140171492-A1 | CHIMERIC RNA OLIGONUCLEOTIDES AND USES THEREOF | UNIVERSITA CATTOLICA DEL SACRO CUORE (IT) | 2014-06-19 | — | — | US | disclosed |
| US-20130236536-A1 | Oligonucleotide Analogues Incorporating 5-Aza-Cytosine Therein | ASTEX PHARMACEUTICALS, INC. (US) | 2013-09-12 | — | — | US | disclosed |
| US-8461123-B2 | Oligonucleotide analogues incorporating 5-aza-cytosine therein | ASTEX PHARMACEUTICALS, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| WO-2012142480-A1 | CHIMERIC RNA OLIGONUCLEOTIDES AND USES THEREOF | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2012-10-18 | — | — | WO | disclosed |
| US-20100215729-A1 | OLIGONUCLEOTIDE ANALOGUES INCORPORATING 5-AZA-CYTOSINE THEREIN | SUPERGEN, INC. | 2010-08-26 | — | — | US | disclosed |
| US-7700567-B2 | methylation modulators; phosphoramidite building blocks; for treating cancer and hematological disorders | SUPERGEN, INC. (US) | 2010-04-20 | — | — | US | disclosed |
| EP-1943264-A2 | OLIGONUCLEOTIDE ANALOGUES INCORPORATING 5-AZA-CYTOSINE THEREIN | SuperGen, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007041071-A2 | OLIGONUCLEOTIDE ANALOGUES INCORPORATING 5-AZA-CYTOSINE THEREIN | SUPERGEN, INC. (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20070072796-A1 | methylation modulators; phosphoramidite building blocks; for treating cancer and hematological disorders | ASTEX PHARMACEUTICALS, INC. | 2007-03-29 | — | — | US | disclosed |