Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6667894 | 0.80 | TSHR (0.44) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL231579 | 0.78 | TSHR (0.42) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL1524035 | 0.78 | TSHR (0.42) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL6990374 | 0.78 | TSHR (0.42) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL2910849 | 0.78 | TSHR (0.42) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL181786 | 0.78 | TSHR (0.42) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL9421561 | 0.76 | TSHR (0.41) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL9421573 | 0.76 | TSHR (0.41) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL6423299 | 0.76 | TSHR (0.47) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| Di(Hydroxyethyl)Ether SCHEMBL2684287 | 0.75 | TSHR (0.50) | TSHRALDH1A1TP53HIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700560-B2 | Inactivators and bivalent inhibitors of glyoxalase I and methods of inhibiting tumor growth | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (US) | 2010-04-20 | — | — | US | disclosed |
| US-20070129311-A1 | Inactivators and bivalent inhibitors of glyoxalase i and methods inhibiting tumor growth | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY | 2007-06-07 | — | — | US | disclosed |
| EP-1628999-A4 | INACTIVATORS AND BIVALENT INHIBITORS OF GLYOXALASE I AND METHODS OF INHIBITING TUMOR GROWTH | UNIV MARYLAND (US) | 2006-08-23 | — | — | EP | disclosed |
| EP-1628999-A2 | INACTIVATORS AND BIVALENT INHIBITORS OF GLYOXALASE I AND METHODS OF INHIBITING TUMOR GROWTH | University of Maryland, Baltimore County (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2005007079-A2 | INACTIVATORS AND BIVALENT INHIBITORS OF GLYOXALASE I AND METHODS OF INHIBITING TUMOR GROWTH | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (US) | 2005-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129311-A1 | Inactivators and bivalent inhibitors of glyoxalase i and methods inhibiting tumor growth | GLS, GLO1, GLRX3 | TSHR 3314/4885ALDH1A1 706/4885TP53 450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.