Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLKL | Q8NB16 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.34 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | MPL | P40238 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
| ▸ | DDO | Q99489 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3279617 | 0.97 | MLKL (0.42) | MLKLKIF11CDK4CCND1CAMK2B | |
| SCHEMBL3286936 | 0.92 | MLKL (0.54) | MLKLRAB9ATP53MAPTALDH1A1 | |
| SCHEMBL3287746 | 0.89 | DAO (0.41) | MLKLRAB9ATP53MAPTALDH1A1 | |
| SCHEMBL3281252 | 0.88 | MLKL (0.53) | MLKLRAB9ATP53MAPTALDH1A1 | |
| SCHEMBL3280623 | 0.88 | MLKL (0.41) | MLKLRAB9ATP53ALDH1A1CYP19A1 | |
| SCHEMBL4504558 | 0.83 | MLKL (0.41) | MLKLKIF11CDK4CCND1CAMK2B | |
| SCHEMBL4501760 | 0.83 | MLKL (0.41) | MLKLKIF11CDK4CCND1CAMK2B | |
| SCHEMBL4501754 | 0.83 | MLKL (0.41) | MLKLKIF11CDK4CCND1CAMK2B | |
| SCHEMBL3280713 | 0.83 | MLKL (0.41) | MLKLMAPTALDH1A1KDM4ELMNA | |
| SCHEMBL4504554 | 0.83 | MLKL (0.41) | MLKLKIF11CDK4CCND1CAMK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705034-B2 | Vinylogous acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-04-27 | — | — | US | claimed |
| EP-2074090-A1 | VINYLOGOUS ACIDS DERIVATIVES AS CHYMASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-07-01 | — | — | EP | claimed |
| US-20080096953-A1 | Vinylogous acid derivatives | HOFFMANN-LA ROCHE INC. | 2008-04-24 | — | — | US | claimed |
| WO-2008043698-A1 | VINYLOGOUS ACIDS DERIVATIVES AS CHYMASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-17 | — | — | WO | claimed |
| US-7705034-B2 | Vinylogous acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-7705034-B2 | Vinylogous acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-7705034-B2 | Vinylogous acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-04-27 | — | — | US | disclosed |
| EP-2074090-A1 | VINYLOGOUS ACIDS DERIVATIVES AS CHYMASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-07-01 | — | — | EP | disclosed |
| US-20080096953-A1 | Vinylogous acid derivatives | HOFFMANN-LA ROCHE INC. | 2008-04-24 | — | — | US | disclosed |
| US-20080096953-A1 | Vinylogous acid derivatives | HOFFMANN-LA ROCHE INC. | 2008-04-24 | — | — | US | disclosed |
| US-20080096953-A1 | Vinylogous acid derivatives | HOFFMANN-LA ROCHE INC. | 2008-04-24 | — | — | US | disclosed |
| WO-2008043698-A1 | VINYLOGOUS ACIDS DERIVATIVES AS CHYMASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-17 | — | — | WO | disclosed |
| WO-2008043698-A1 | VINYLOGOUS ACIDS DERIVATIVES AS CHYMASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096953-A1 | Vinylogous acid derivatives | CMA1, TPSG1, GAA | MLKL 4134/4885KIF11 4029/4885CDK4 1793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.