TPSG1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL951611	0.58	16/20
SCHEMBL3332397	0.68	15/20
SCHEMBL3335469	0.68	15/20
SCHEMBL3337061	0.56	14/20
SCHEMBL3339780	0.60	10/20
SCHEMBL3339769	0.59	10/20
SCHEMBL3336049	0.54	9/20
SCHEMBL1668497	0.53	9/20
SCHEMBL3328351	0.48	9/20
SCHEMBL3337050	0.53	8/20
SCHEMBL3337054	0.53	8/20
SCHEMBL1668863	0.51	8/20
SCHEMBL389996	0.46	8/20
SCHEMBL1669095	0.53	7/20
SCHEMBL1668474	0.52	7/20
SCHEMBL329382	0.47	7/20
SCHEMBL2344320	0.46	7/20
SCHEMBL3163506	0.43	7/20
SCHEMBL1668904	0.54	6/20
SCHEMBL953680	0.54	6/20

Clinical trials — most relevant to TPSG1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Montelukast in Preventing Dengue With Warning Signs in Dengue Patients	PHASE2/PHASE3	COMPLETED
Interest of Denosumab Treatment in Osteoporosis Associated to Systemic Mastocytosis	PHASE3	COMPLETED
Effects of Anti-TSLP in Patients With Asthma	PHASE2	COMPLETED
The Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Allergic Reaction to an Initial Dose	PHASE2	COMPLETED
Evaluation of Response to Use of Intravesical Ozone Gas in Interstitial Cystitis /Bladder Pain Syndrome	PHASE2	UNKNOWN
A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis	PHASE2	COMPLETED
Role of Tryptase Levels in Patients With Stable Coronary Artery Disease.	nan	RECRUITING
Chemokine Mechanisms in Chronic Pelvic Pain	nan	COMPLETED
Blood Factors in Mastocytosis and Unexplained Anaphylaxis and Flushing	nan	COMPLETED
Tryptase Level as a Marker of Complications in Transcatheter Aortic Valve Replacement	nan	UNKNOWN
Improvement of Foodallergy Diagnostic in Gastrointestinal Tract	nan	COMPLETED
Investigation of the Frequency of Hereditary Hyper Alpha-tryptasemia in Patients With Elevated Basal Tryptasemia	nan	ACTIVE_NOT_RECRUITING
In Vivo Assessment of Histamine Pharmacodynamics	nan	WITHDRAWN
Dosage of Serum Tryptase Levels in a Population of Premature Newborns to Evaluate Mast Cell Activity	nan	COMPLETED
Cause and Natural Course of Pediatric-Onset Mastocytosis	nan	COMPLETED
Assessment of Burden Disease in Patients With Mast Cell Disorders	nan	UNKNOWN
Effect of FODMAPs on Mucosal Inflammation in IBS Patients	nan	UNKNOWN
Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations	nan	COMPLETED
Inflammatory Processes in the Airway of Asthmatics With Persistent Bronchial Hyperreactivity	nan	COMPLETED
Allergy and Immunology Natural History Study	nan	RECRUITING
GI Alpha-Gal Study	nan	COMPLETED
Persistence of Sensitization to Contrast Media	nan	NOT_YET_RECRUITING
Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy Individuals	nan	COMPLETED
Are Mast Cells Involved in Autoinflammatory Diseases	nan	NOT_YET_RECRUITING
Mast Cells and Its Proteases in COPD	nan	UNKNOWN
Perioperative Anaphylaxis in Patients Attending University Hospitals (Egypt - UK).	nan	COMPLETED
Applying Systems Immunology to the Search for Personalized Biomarkers of Clinical Efficacy	nan	COMPLETED
Tryptase and Coronary Heart Disease	nan	COMPLETED
Cause of Unexplained Anaphylaxis	nan	ACTIVE_NOT_RECRUITING
Diagnostic Value of Bone Marrow Tryptase in Systemic Mastocytosis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TPSG1 binder may also engage these)

Protein	Name	Similarity
Q80WM7	—	0.991	Q80WM7 →
Q9QUL7	—	0.987	Q9QUL7 →
P83748	—	0.987	P83748 →
PRSS8	Prostasin	0.981	landscape →
Q9GZN4	—	0.981	Q9GZN4 →
Q6IE59	—	0.981	Q6IE59 →
Q9QYZ9	—	0.981	Q9QYZ9 →
Q9Y6M0	—	0.979	Q9Y6M0 →
Q9ESD1	—	0.979	Q9ESD1 →
Q5K4E3	—	0.978	Q5K4E3 →
Q14B24	—	0.978	Q14B24 →
Q5K2P8	—	0.977	Q5K2P8 →
Q9XSM2	—	0.977	Q9XSM2 →
P15944	—	0.977	P15944 →
Q7RTY9	—	0.977	Q7RTY9 →
Q6UWY2	—	0.977	Q6UWY2 →
A6NIE9	—	0.977	A6NIE9 →
Q2L4Q9	—	0.975	Q2L4Q9 →
TPSD1	Tryptase delta (EC 3.4.21.59) (Delta-tryptase	0.974	landscape →
O43240	—	0.974	O43240 →
Q9H3S3	—	0.973	Q9H3S3 →
Q5K2P9	—	0.973	Q5K2P9 →
P19236	—	0.972	P19236 →
Q7Z5A4	—	0.972	Q7Z5A4 →
Q9N2D1	—	0.971	Q9N2D1 →
Q571E5	—	0.971	Q571E5 →
Q9BQR3	—	0.970	Q9BQR3 →
Q6BEA2	—	0.970	Q6BEA2 →
Q14B25	—	0.969	Q14B25 →
Q9ES87	—	0.969	Q9ES87 →