Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 7/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.41 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.41 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | CATSPER1 | Q8NEC5 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280055 | 0.80 | PTPN1 (0.54) | PTPN1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL279943 | 0.78 | PTPN1 (0.53) | PTPN1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13349507 | 0.76 | TARBP2 (0.48) | PTPN1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL280227 | 0.74 | PTPN1 (0.48) | PTPN1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28877126 | 0.71 | PTPN1 (0.44) | PTPN1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2567880 | 0.70 | PTPN1 (1.00) | PTPN1ALDH1A1DUSP3IP6K1IP6K3 | |
| SCHEMBL11128848 | 0.70 | PTGS1 (0.51) | PTPN1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4076415 | 0.69 | PTPN1 (0.67) | PTPN1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL17079305 | 0.69 | PTPN1 (0.67) | PTPN1ALDH1A1MEN1KMT2ADUSP3 | |
| SCHEMBL15891186 | 0.67 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318796-B2 | Heterocyclic compounds and thrombopoietin receptor activators | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2012-11-27 | — | — | US | disclosed |
| US-8134013-B2 | Amide compound and thrombopoietin receptor activator | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2012-03-13 | — | — | US | disclosed |
| US-20110077290-A1 | HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES LIMITED (JP) | 2011-03-31 | — | — | US | disclosed |
| US-20090131659-A1 | AMIDE COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077290-A1 | HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NR2C2, ROR1, NR0B2 | PTPN1 1416/4885ALDH1A1 3234/4885SMN1; SMN2 2016/4885 |
| US-20090131659-A1 | AMIDE COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR | TEK, PTAFR, MPL | PTPN1 1638/4885ALDH1A1 2047/4885SMN1; SMN2 1437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.