Sugi Predict

Sugi Predict / Compounds / SCHEMBL3282340

SCHEMBL3282340

SCHEMBL3282340

O=c1ccc2cccc(Br)c2o1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP2A6 P11509 1/20 0.55
▸ MCL1 Q07820 3/20 0.47
▸ LMNA P02545 2/20 0.47
▸ TDP1 Q9NUW8 2/20 0.47
▸ ALDH1A1 P00352 2/20 0.47
▸ KDM4E B2RXH2 1/20 0.47
▸ PRKD3 O94806 1/20 0.47
▸ EGFR P00533 1/20 0.47
▸ PRKCG P05129 1/20 0.47
▸ CYP1A2 P05177 1/20 0.47
▸ PRKCB P05771 1/20 0.47
▸ POLB P06746 1/20 0.47
▸ CYP3A4 P08684 1/20 0.47
▸ CYP2D6 P10635 1/20 0.47
▸ MAPT P10636 1/20 0.47
▸ THRB P10828 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ ALOX15 P16050 1/20 0.47
▸ PRKCA P17252 1/20 0.47
▸ PRKACA P17612 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30524350 0.78 CYP2A6 (0.58) CYP2A6MCL1LMNATDP1ALDH1A1
SCHEMBL5535389 0.77 CYP2A6 (0.56) CYP2A6MCL1LMNATDP1ALDH1A1
SCHEMBL836924 0.75 CYP2A6 (0.59) CYP2A6MCL1LMNATDP1ALDH1A1
SCHEMBL9180513 0.75 CYP2A6 (0.55) CYP2A6MCL1LMNATDP1ALDH1A1
SCHEMBL10602660 0.75 CYP2A6 (0.55) CYP2A6MCL1LMNATDP1ALDH1A1
8-Hydroxycoumarin SCHEMBL1366927 0.75 MCL1 (0.62) CYP2A6MCL1LMNATDP1ALDH1A1
SCHEMBL17579563 0.75 CYP2A6 (0.55) CYP2A6MCL1LMNATDP1ALDH1A1
SCHEMBL8684869 0.75 CYP2A6 (0.55) CYP2A6MCL1LMNATDP1ALDH1A1
Hydrochloric Acid SCHEMBL7409340 0.73 CYP2A6 (0.53) CYP2A6MCL1LMNATDP1ALDH1A1
SCHEMBL6226548 0.73 GPR35 (0.49) CYP2A6MCL1LMNATDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240174650-A1 8-(PICOLINAMIDE) SUBSTITUTED COUMARIN COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF LONGIVITRON (SUZHOU) BIOTECHNOLOGY CO., LTD (CN) 2024-05-30 — — US claimed
EP-4303219-A1 8-(PICOLINAMIDE) SUBSTITUTED COUMARIN COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF Longivitron (Suzhou) Biotechnology Co., Ltd (CN) 2024-01-10 — — EP claimed
CN-113149971-B 8- (indoletriazole) substituted coumarin compound and preparation method and application thereof 港科鹏禾生物(苏州)有限公司 2022-12-16 — — CN claimed
CN-113149970-B 8- (pyridine triazole) substituted coumarin compound and preparation method and application thereof 朗捷睿(苏州)生物科技有限公司 2022-12-09 — — CN claimed
CN-113149979-B 8- (benzothiazole amide) substituted coumarin compound and preparation method and application thereof 朗捷睿(苏州)生物科技有限公司 2022-11-25 — — CN claimed
CN-112939955-B 8- (pyridine amide) substituted coumarin compound and preparation method and application thereof 朗捷睿(苏州)生物科技有限公司 2022-10-21 — — CN claimed
WO-2022183963-A1 8-(PICOLINAMIDE) SUBSTITUTED COUMARIN COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF 朗捷睿(苏州)生物科技有限公司 2022-09-09 — — WO claimed
WO-2022183964-A1 8-(PYRIDINE TRIAZOLE) SUBSTITUTED COUMARIN-TYPE COMPOUND, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 朗捷睿(苏州)生物科技有限公司 2022-09-09 — — WO claimed
WO-2022183961-A1 8-(BENZOTHIAZOLE AMIDE) SUBSTITUTED COUMARIN COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 朗捷睿(苏州)生物科技有限公司 2022-09-09 — — WO claimed
CN-113149979-A 8- (benzothiazole amide) substituted coumarin compound and preparation method and application thereof 朗捷睿(苏州)生物科技有限公司 2021-07-23 — — CN claimed
CN-113149970-A 8- (pyridine triazole) substituted coumarin compound and preparation method and application thereof 朗捷睿(苏州)生物科技有限公司 2021-07-23 — — CN claimed
CN-113149971-A 8- (indoletriazole) substituted coumarin compound and preparation method and application thereof 港科鹏禾生物(苏州)有限公司 2021-07-23 — — CN claimed
CN-112939955-A 8- (pyridine amide) substituted coumarin compound and preparation method and application thereof 朗捷睿(苏州)生物科技有限公司 2021-06-11 — — CN claimed
US-20240174650-A1 8-(PICOLINAMIDE) SUBSTITUTED COUMARIN COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF LONGIVITRON (SUZHOU) BIOTECHNOLOGY CO., LTD (CN) 2024-05-30 — — US disclosed
EP-4303219-A1 8-(PICOLINAMIDE) SUBSTITUTED COUMARIN COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF Longivitron (Suzhou) Biotechnology Co., Ltd (CN) 2024-01-10 — — EP disclosed
CN-113149971-B 8- (indoletriazole) substituted coumarin compound and preparation method and application thereof 港科鹏禾生物(苏州)有限公司 2022-12-16 — — CN disclosed
US-4441969-A ARYL HYDROXY CARBOXYLIC ACID OMI INTERNATIONAL CORPORATION (US) 1984-04-10 — — US disclosed
US-4362741-A 3-DIETHYLAMINOETHYLCOUMARINS FIDIA, S.P.A. (IT) 1982-12-07 — — US disclosed
US-4349566-A Treatment of arrhythmia with 8-chloro- or 8-bromocoumarin derivatives FIDIA S.P.A. (IT) 1982-09-14 — — US disclosed
US-4349566-A Treatment of arrhythmia with 8-chloro- or 8-bromocoumarin derivatives FIDIA S.P.A. (IT) 1982-09-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240174650-A1 8-(PICOLINAMIDE) SUBSTITUTED COUMARIN COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF SIRT2, SIRT1, SIRT7 CYP2A6 1452/4885MCL1 1885/4885LMNA 377/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.