Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13071332 | 0.89 | CHRM1 (0.43) | KMOPOLBTSHRDRD2HTR2A | |
| SCHEMBL8266002 | 0.85 | POLB (0.49) | KMOPOLBTP53RENHTT | |
| SCHEMBL8265502 | 0.85 | POLB (0.49) | KMOPOLBTP53RENHTT | |
| SCHEMBL8265365 | 0.84 | POLB (0.56) | KMOPOLBTP53HTTTSHR | |
| SCHEMBL4096802 | 0.84 | KMO (0.50) | KMOPOLBTP53HTTTSHR | |
| SCHEMBL4102493 | 0.84 | TSHR (0.62) | POLBTP53HTTTSHRTHRB | |
| SCHEMBL8879021 | 0.83 | HTT (0.54) | KMOPOLBTP53RENHTT | |
| SCHEMBL5799186 | 0.83 | KMO (0.52) | KMOPOLBTP53HTTTSHR | |
| SCHEMBL55503 | 0.83 | REN (0.61) | KMOPOLBTP53RENHTT | |
| SCHEMBL8264865 | 0.82 | REN (0.57) | KMOPOLBTP53RENHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428508-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2012-03-14 | — | — | EP | disclosed |