Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3081301 | 0.82 | HRH3 (0.69) | HRH3HRH1 | |
| SCHEMBL778932 | 0.82 | NPC1 (0.49) | HRH3HRH1 | |
| SCHEMBL12653312 | 0.79 | OPRM1 (0.46) | HRH3HRH1 | |
| SCHEMBL6176295 | 0.79 | KDM4E (0.54) | HRH3HRH1HSD17B10 | |
| SCHEMBL14997973 | 0.78 | HRH3 (0.47) | HRH3HRH1 | |
| SCHEMBL8358334 | 0.78 | KDM4E (0.50) | HRH3HRH1 | |
| SCHEMBL14380137 | 0.78 | ALDH1A1 (0.57) | HRH3HRH1ALOX15TSHRHSD17B10 | |
| SCHEMBL4400002 | 0.76 | HRH3 (0.47) | HRH3HRH1 | |
| SCHEMBL21580740 | 0.76 | HRH3 (0.45) | HRH3ALOX15TSHRHSD17B10 | |
| SCHEMBL5430656 | 0.75 | ESR2 (0.47) | HRH3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014028334-A1 | SELECTIVE MMP INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2014-02-20 | — | — | WO | disclosed |
| EP-1511488-B1 | HUMAN ADAM-10 INHIBITORS | SYMPHONY EVOLUTION INC (US) | 2013-05-22 | — | — | EP | disclosed |
| EP-2436676-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-04-04 | — | — | EP | disclosed |
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |