Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12734153 | 0.86 | KDM4E (0.47) | RAB9ANPC1KDM4EPOLBMEN1 | |
| SCHEMBL4597506 | 0.84 | KDM4E (0.54) | RAB9ANPC1KDM4EPOLBMEN1 | |
| SCHEMBL8737052 | 0.80 | KDM4E (0.66) | RAB9ANPC1KDM4EPOLBMEN1 | |
| SCHEMBL8736734 | 0.77 | KDM4E (0.57) | RAB9ANPC1KDM4EPOLBMEN1 | |
| SCHEMBL21581572 | 0.77 | DRD1 (0.45) | NPC1KDM4EPTPN1TRPA1POLB | |
| SCHEMBL8736869 | 0.77 | HAO1 (0.51) | RAB9ANPC1KDM4EPOLBMEN1 | |
| SCHEMBL13183652 | 0.76 | ALDH1A1 (0.51) | RAB9ANPC1KDM4EPOLBMEN1 | |
| SCHEMBL23952709 | 0.75 | KDM4E (0.46) | RAB9ANPC1KDM4EPOLBMEN1 | |
| SCHEMBL4598049 | 0.75 | KDM4E (0.56) | RAB9ANPC1KDM4EPOLBMEN1 | |
| SCHEMBL17354612 | 0.74 | KDM4E (0.44) | RAB9ANPC1KDM4EPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |