Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RHEB | Q15382 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1093032 | 1.00 | ROCK2 (0.35) | ROCK2CHKAALDH1A1L3MBTL1CMA1 | |
| SCHEMBL1092227 | 0.92 | ROCK2 (0.35) | ROCK2CMA1PDE4APDE4BPDE4C | |
| SCHEMBL1094079 | 0.92 | ROCK2 (0.35) | ROCK2CMA1PDE4APDE4BPDE4C | |
| SCHEMBL1092143 | 0.91 | CHKA (0.34) | CHKAALDH1A1L3MBTL1PDE4APDE4B | |
| SCHEMBL1092145 | 0.91 | CHKA (0.34) | CHKAALDH1A1L3MBTL1PDE4APDE4B | |
| SCHEMBL1091733 | 0.87 | LRRK2 (0.35) | ROCK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1091734 | 0.87 | LRRK2 (0.35) | ROCK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4345635 | 0.85 | P2RX3 (0.34) | ROCK2ALDH1A1CHRM2MEN1KMT2A | |
| SCHEMBL1092636 | 0.83 | ROCK2 (0.33) | ROCK2 | |
| SCHEMBL1092633 | 0.83 | ROCK2 (0.33) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021336-B1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2010-06-30 | — | — | EP | disclosed |